Impact of metabolic syndrome on subclinical atherosclerosis in asymptomatic individuals

Gyung Min Park, Hyonggin An, Seung Whan Lee, Young Rak Cho, Eun Ha Gil, Sung Ho Her, Hyun Woo Park, Jung Min Ahn, Duk Woo Park, Soo Jin Kang, Young Hak Kim, Cheol Whan Lee, Dong Hyun Yang, Joon Won Kang, Tae Hwan Lim, Hong Kyu Kim, Jaewon Choe, Seong Wook Park, Seung Jung Park

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Abstract

Background: Little is known about subclinical atherosclerosis on coronary computed tomographic angiography (CCTA) in asymptomatic individuals with metabolic syndrome (MetS). Methods and Results: We analyzed 5,213 asymptomatic individuals who underwent CCTA. A cardiac event was defined as a composite of all-cause death, myocardial infarction, unstable angina, or coronary revascularization. Of the study participants, 2,042 (39.2%) had MetS. MetS was an independent predictor of significant coronary artery disease (CAD) in at least 1 coronary artery (odds ratio [OR]=1.992, 95% confidence interval [CI]=1.623–2.445, P<0.001) and significant CAD in the left main (LM) or proximal left anterior descending (LAD) artery (OR=2.151, 95% CI=1.523–3.037, P<0.001). During the follow-up period (median 28.1 [interquartile range, 19.2–36.5] months), 111 individuals had 114 cardiac events. Individuals with MetS were significantly associated with more cardiac events than those without (RR [rate ratio]=1.67, 95% CI=1.15–2.43, P=0.007). In the MetS group, individuals with significant CAD had the majority of cardiac events (RR=64.33, 95% CI=29.17–141.88, P<0.001). Furthermore, in the MetS with significant CAD group, those with significant CAD in the LM or proximal LAD had more cardiac events (RR=2.63, 95% CI=1.51–4.59, P=0.001). Conclusions: MetS was associated with subclinical atherosclerosis on CCTA with subsequent high risk for cardiac events. These findings suggest the importance of reducing unfavorable metabolic conditions in asymptomatic individuals.

Original languageEnglish
Pages (from-to)1799-1806
Number of pages8
JournalCirculation Journal
Volume79
Issue number8
DOIs
Publication statusPublished - 2015 Jan 1

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Keywords

  • Atherosclerosis
  • Coronary artery disease
  • Metabolic syndrome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Park, G. M., An, H., Lee, S. W., Cho, Y. R., Gil, E. H., Her, S. H., Park, H. W., Ahn, J. M., Park, D. W., Kang, S. J., Kim, Y. H., Lee, C. W., Yang, D. H., Kang, J. W., Lim, T. H., Kim, H. K., Choe, J., Park, S. W., & Park, S. J. (2015). Impact of metabolic syndrome on subclinical atherosclerosis in asymptomatic individuals. Circulation Journal, 79(8), 1799-1806. https://doi.org/10.1253/circj.CJ-14-1197