Impact of model-based iterative reconstruction on the correlation between computed tomography quantification of a low lung attenuation area and airway measurements and pulmonary function test results in normal subjects

Da Jung Kim, Cherry Kim, Chol Shin, Seung Ku Lee, Chang Sub Ko, Ki Yeol Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To compare correlations between pulmonary function test (PFT) results and different reconstruction algorithms and to suggest the optimal reconstruction protocol for computed tomography (CT) quantification of low lung attenuation areas and airways in healthy individuals. Materials and Methods: A total of 259 subjects with normal PFT and chest CT results were included. CT scans were reconstructed using filtered back projection, hybrid-iterative reconstruction, and model–based IR (MIR). For quantitative analysis, the emphysema index (EI) and wall area percentage (WA%) were determined. Subgroup analysis according to smoking history was also performed. Results: The EIs of all the reconstruction algorithms correlated significantly with the forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) (all p < 0.001). The EI of MIR showed the strongest correlation with FEV1/FVC (r =-0.437). WA% showed a significant correlation with FEV1 in all the reconstruction algorithms (all p < 0.05) correlated significantly with FEV1/FVC for MIR only (p < 0.001). The WA% of MIR showed the strongest correlations with FEV1 (r =-0.205) and FEV1/FVC (r =-0.250). In subgroup analysis, the EI of MIR had the strongest correlation with PFT in both ever-smoker and never-smoker subgroups, although there was no significant difference in the EI between the reconstruction algorithms. WA% of MIR showed a significantly thinner airway thickness than the other algorithms (49.7 ± 7.6 in ever-smokers and 49.5 ± 7.5 in never-smokers, all p < 0.001), and also showed the strongest correlation with PFT in both ever-smoker and never-smoker subgroups. Conclusion: CT quantification of low lung attenuation areas and airways by means of MIR showed the strongest correlation with PFT results among the algorithms used, in normal subjects.

Original languageEnglish
Pages (from-to)1187-1195
Number of pages9
JournalKorean journal of radiology
Volume19
Issue number6
DOIs
Publication statusPublished - 2018 Nov 1

Keywords

  • Airway
  • Computed tomography
  • Iterative reconstruction
  • Pulmonary emphysema
  • Pulmonary function test

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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