Abstract
Background and aims: Since clinical characteristics and prognosis of patients with multi-vessel vasospastic angina (VSA) are not clear, we investigated the nature and prognosis of multi-vessel VSA in Koreans. Methods: Among 2960 patients enrolled in the VA-KOREA (Vasospastic Angina in Korea) registry, 104 definite multi-vessel VSA patients, 163 single vessel VSA patients and 737 non-VSA patients were identified using the intracoronary ergonovine provocation test. Results: Multi-vessel VSA and single vessel VSA groups showed similar baseline characteristics and medical treatment on discharge, but different from the non-VSA group. The primary composite endpoint (cardiac death, acute coronary syndrome, and symptomatic new onset arrhythmia) over a 36-month follow-up period was significantly higher in the multi-vessel VSA group than in the single vessel VSA and non-VSA groups (8.7% vs. 1.8% and 1.1%, each log-rank p < 0.05, respectively). The rate of death and acute coronary syndrome of the multi-vessel VSA group was higher than in the single vessel VSA and non-VSA groups (5.8% vs. 1.2% and 0.9%, each log-rank p < 0.05, respectively). In addition, multi-vessel VSA was an independent predictor of the primary composite endpoint at 36 months (HR 8.5, 95% CI [2.6–27.2], p < 0.0001). Conclusions: Patients with multi-vessel VSA had worse clinical outcomes than single vessel VSA and non-VSA groups, suggesting that the existence of multi-vessel VSA itself is highly prognostic.
| Original language | English |
|---|---|
| Pages (from-to) | 107-113 |
| Number of pages | 7 |
| Journal | Atherosclerosis |
| Volume | 281 |
| DOIs | |
| Publication status | Published - 2019 Feb 1 |
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Keywords
- Coronary artery disease
- Multi-vessel
- Prognosis
- Vasospasm
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Impact of multi-vessel vasospastic angina on cardiovascular outcome. / Han, Seung Hwan; Lee, Kwan Yong; Her, Sung Ho; Ahn, Youngkeun; Park, Keun Ho; Kim, Dong Soo; Yang, Tae Hyun; Choi, Dong Ju; Suh, Jung Won; Kwon, Hyuck Moon; Lee, Byoung Kwon; Gwon, Hyeon Cheol; Rha, Seung-Woon; Jo, Sang Ho; Ko, Kwang Pil; Baek, Sang Hong.
In: Atherosclerosis, Vol. 281, 01.02.2019, p. 107-113.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Impact of multi-vessel vasospastic angina on cardiovascular outcome
AU - Han, Seung Hwan
AU - Lee, Kwan Yong
AU - Her, Sung Ho
AU - Ahn, Youngkeun
AU - Park, Keun Ho
AU - Kim, Dong Soo
AU - Yang, Tae Hyun
AU - Choi, Dong Ju
AU - Suh, Jung Won
AU - Kwon, Hyuck Moon
AU - Lee, Byoung Kwon
AU - Gwon, Hyeon Cheol
AU - Rha, Seung-Woon
AU - Jo, Sang Ho
AU - Ko, Kwang Pil
AU - Baek, Sang Hong
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Background and aims: Since clinical characteristics and prognosis of patients with multi-vessel vasospastic angina (VSA) are not clear, we investigated the nature and prognosis of multi-vessel VSA in Koreans. Methods: Among 2960 patients enrolled in the VA-KOREA (Vasospastic Angina in Korea) registry, 104 definite multi-vessel VSA patients, 163 single vessel VSA patients and 737 non-VSA patients were identified using the intracoronary ergonovine provocation test. Results: Multi-vessel VSA and single vessel VSA groups showed similar baseline characteristics and medical treatment on discharge, but different from the non-VSA group. The primary composite endpoint (cardiac death, acute coronary syndrome, and symptomatic new onset arrhythmia) over a 36-month follow-up period was significantly higher in the multi-vessel VSA group than in the single vessel VSA and non-VSA groups (8.7% vs. 1.8% and 1.1%, each log-rank p < 0.05, respectively). The rate of death and acute coronary syndrome of the multi-vessel VSA group was higher than in the single vessel VSA and non-VSA groups (5.8% vs. 1.2% and 0.9%, each log-rank p < 0.05, respectively). In addition, multi-vessel VSA was an independent predictor of the primary composite endpoint at 36 months (HR 8.5, 95% CI [2.6–27.2], p < 0.0001). Conclusions: Patients with multi-vessel VSA had worse clinical outcomes than single vessel VSA and non-VSA groups, suggesting that the existence of multi-vessel VSA itself is highly prognostic.
AB - Background and aims: Since clinical characteristics and prognosis of patients with multi-vessel vasospastic angina (VSA) are not clear, we investigated the nature and prognosis of multi-vessel VSA in Koreans. Methods: Among 2960 patients enrolled in the VA-KOREA (Vasospastic Angina in Korea) registry, 104 definite multi-vessel VSA patients, 163 single vessel VSA patients and 737 non-VSA patients were identified using the intracoronary ergonovine provocation test. Results: Multi-vessel VSA and single vessel VSA groups showed similar baseline characteristics and medical treatment on discharge, but different from the non-VSA group. The primary composite endpoint (cardiac death, acute coronary syndrome, and symptomatic new onset arrhythmia) over a 36-month follow-up period was significantly higher in the multi-vessel VSA group than in the single vessel VSA and non-VSA groups (8.7% vs. 1.8% and 1.1%, each log-rank p < 0.05, respectively). The rate of death and acute coronary syndrome of the multi-vessel VSA group was higher than in the single vessel VSA and non-VSA groups (5.8% vs. 1.2% and 0.9%, each log-rank p < 0.05, respectively). In addition, multi-vessel VSA was an independent predictor of the primary composite endpoint at 36 months (HR 8.5, 95% CI [2.6–27.2], p < 0.0001). Conclusions: Patients with multi-vessel VSA had worse clinical outcomes than single vessel VSA and non-VSA groups, suggesting that the existence of multi-vessel VSA itself is highly prognostic.
KW - Coronary artery disease
KW - Multi-vessel
KW - Prognosis
KW - Vasospasm
UR - http://www.scopus.com/inward/record.url?scp=85059912282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059912282&partnerID=8YFLogxK
U2 - 10.1016/j.atherosclerosis.2018.12.018
DO - 10.1016/j.atherosclerosis.2018.12.018
M3 - Article
C2 - 30658185
AN - SCOPUS:85059912282
VL - 281
SP - 107
EP - 113
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
ER -