Impact of old age on clinical and angiographic characteristics of coronary artery spasm as assessed by acetylcholine provocation test

Woong Gil Choi, Soo Hyun Kim, Seung-Woon Rha, Kang Yin Chen, Yong Jian Li, Byoung Geol Choi, Se Yeon Choi, Jin Won Kim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background Smoking and other risk factors have been well known as important factors of variant angina or coronary artery spasm (CAS). However, clinical features related to age on coronary artery spasm have been rarely evaluated. Methods We evaluated 3155 consecutive patients with insignificant coronary artery lesion. Patients underwent Acetylcholine (Ach) provocation test for induction of CAS. CAS was defined as < 70% luminal narrowing of coronary arteries during Ach provocation test. The results of Ach provocation test were compared among age groups; > 45 years (Group 1), 45-54 years (Group 2), 55-64 years (Group 3), and = 65 years (Group 4). Results Older patients had higher incidence of hypertension, diabetes, but lower incidence rate of current smoking, male sex compared with younger patients. Positive Ach provocation test finding was frequently showed with aging (47.36% vs. 58.3% vs. 62.6% vs. 61.5%; P > 0.001). Multivariate logistic analysis showed that age, male, and myocardial bridge were independent predictors of CAS induced by Ach provocation test. Conclusion Our present study showed that old age was independent predictor for Ach-induced significant coronary artery spasm.

Original languageEnglish
Pages (from-to)824-829
Number of pages6
JournalJournal of Geriatric Cardiology
Volume13
Issue number10
DOIs
Publication statusPublished - 2016

Fingerprint

Spasm
Acetylcholine
Coronary Vessels
Smoking
Incidence
Multivariate Analysis
Hypertension

Keywords

  • Acetylcholine
  • Age factor
  • Coronary vasospasm

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cardiology and Cardiovascular Medicine

Cite this

Impact of old age on clinical and angiographic characteristics of coronary artery spasm as assessed by acetylcholine provocation test. / Choi, Woong Gil; Kim, Soo Hyun; Rha, Seung-Woon; Chen, Kang Yin; Li, Yong Jian; Choi, Byoung Geol; Choi, Se Yeon; Kim, Jin Won; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Oh, Dong Joo.

In: Journal of Geriatric Cardiology, Vol. 13, No. 10, 2016, p. 824-829.

Research output: Contribution to journalArticle

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abstract = "Background Smoking and other risk factors have been well known as important factors of variant angina or coronary artery spasm (CAS). However, clinical features related to age on coronary artery spasm have been rarely evaluated. Methods We evaluated 3155 consecutive patients with insignificant coronary artery lesion. Patients underwent Acetylcholine (Ach) provocation test for induction of CAS. CAS was defined as < 70{\%} luminal narrowing of coronary arteries during Ach provocation test. The results of Ach provocation test were compared among age groups; > 45 years (Group 1), 45-54 years (Group 2), 55-64 years (Group 3), and = 65 years (Group 4). Results Older patients had higher incidence of hypertension, diabetes, but lower incidence rate of current smoking, male sex compared with younger patients. Positive Ach provocation test finding was frequently showed with aging (47.36{\%} vs. 58.3{\%} vs. 62.6{\%} vs. 61.5{\%}; P > 0.001). Multivariate logistic analysis showed that age, male, and myocardial bridge were independent predictors of CAS induced by Ach provocation test. Conclusion Our present study showed that old age was independent predictor for Ach-induced significant coronary artery spasm.",
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AU - Kim, Soo Hyun

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AU - Chen, Kang Yin

AU - Li, Yong Jian

AU - Choi, Byoung Geol

AU - Choi, Se Yeon

AU - Kim, Jin Won

AU - Kim, Eung Ju

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

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N2 - Background Smoking and other risk factors have been well known as important factors of variant angina or coronary artery spasm (CAS). However, clinical features related to age on coronary artery spasm have been rarely evaluated. Methods We evaluated 3155 consecutive patients with insignificant coronary artery lesion. Patients underwent Acetylcholine (Ach) provocation test for induction of CAS. CAS was defined as < 70% luminal narrowing of coronary arteries during Ach provocation test. The results of Ach provocation test were compared among age groups; > 45 years (Group 1), 45-54 years (Group 2), 55-64 years (Group 3), and = 65 years (Group 4). Results Older patients had higher incidence of hypertension, diabetes, but lower incidence rate of current smoking, male sex compared with younger patients. Positive Ach provocation test finding was frequently showed with aging (47.36% vs. 58.3% vs. 62.6% vs. 61.5%; P > 0.001). Multivariate logistic analysis showed that age, male, and myocardial bridge were independent predictors of CAS induced by Ach provocation test. Conclusion Our present study showed that old age was independent predictor for Ach-induced significant coronary artery spasm.

AB - Background Smoking and other risk factors have been well known as important factors of variant angina or coronary artery spasm (CAS). However, clinical features related to age on coronary artery spasm have been rarely evaluated. Methods We evaluated 3155 consecutive patients with insignificant coronary artery lesion. Patients underwent Acetylcholine (Ach) provocation test for induction of CAS. CAS was defined as < 70% luminal narrowing of coronary arteries during Ach provocation test. The results of Ach provocation test were compared among age groups; > 45 years (Group 1), 45-54 years (Group 2), 55-64 years (Group 3), and = 65 years (Group 4). Results Older patients had higher incidence of hypertension, diabetes, but lower incidence rate of current smoking, male sex compared with younger patients. Positive Ach provocation test finding was frequently showed with aging (47.36% vs. 58.3% vs. 62.6% vs. 61.5%; P > 0.001). Multivariate logistic analysis showed that age, male, and myocardial bridge were independent predictors of CAS induced by Ach provocation test. Conclusion Our present study showed that old age was independent predictor for Ach-induced significant coronary artery spasm.

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