Impact of parenchymal tuberculosis sequelae on mediastinal lymph node staging in patients with lung cancer

Seung Heon Lee, Joo Won Min, Chang Hoon Lee, Chang Min Park, Jin Mo Goo, Doo Hyun Chung, Chang Hyun Kang, Young Tae Kim, Young Whan Kim, Sung Koo Han, Young Soo Shim, Jae Joon Yim

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Because tuberculous (TB) involvement of mediastinal lymph nodes (LN) could cause false positive results in nodal staging of lung cancer, we examined the accuracy of nodal staging in lung cancer patients with radiographic sequelae of healed TB. A total of 54 lung cancer patients with radiographic TB sequelae in the lung parenchyma ipsilateral to the resected lung, who had undergone at least ipsilateral 4- and 7-lymph node dissection after both chest computed tomography (CT) and fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT were included for the analysis. The median age of 54 subjects was 66 yr and 48 were males. Calcified nodules and fibrotic changes were the most common forms of healed parenchymal pulmonary TB. Enlarged mediastinal lymph nodes (short diameter > 1 cm) were identified in 21 patients and positive mediastinal lymph nodes were identified using FDG-PET/CT in 19 patients. The overall sensitivity and specificity for mediastinal node metastasis were 60.0% and 69.2% with CT and 46.7% and 69.2% with FDG-PET/CT, respectively. In conclusion, the accuracy of nodal staging using CT or FDG-PET/CT might be low in lung cancer patients with parenchymal TB sequelae, because of inactive TB lymph nodes without viable TB bacilli.

    Original languageEnglish
    Pages (from-to)67-70
    Number of pages4
    JournalJournal of Korean medical science
    Volume26
    Issue number1
    DOIs
    Publication statusPublished - 2011 Jan

    Keywords

    • Latent tuberculosis
    • Lung neoplasms
    • Lymph node
    • Mediastinum
    • Tuberculosis

    ASJC Scopus subject areas

    • Medicine(all)

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