Impact of parenchymal tuberculosis sequelae on mediastinal lymph node staging in patients with lung cancer

Seung Heon Lee, Joo Won Min, Chang Hoon Lee, Chang Min Park, Jin Mo Goo, Doo Hyun Chung, Chang Hyun Kang, Young Tae Kim, Young Whan Kim, Sung Koo Han, Young Soo Shim, Jae Joon Yim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Because tuberculous (TB) involvement of mediastinal lymph nodes (LN) could cause false positive results in nodal staging of lung cancer, we examined the accuracy of nodal staging in lung cancer patients with radiographic sequelae of healed TB. A total of 54 lung cancer patients with radiographic TB sequelae in the lung parenchyma ipsilateral to the resected lung, who had undergone at least ipsilateral 4- and 7-lymph node dissection after both chest computed tomography (CT) and fluorodeoxyglucose (FDG)-positron emission tomography (PET)/CT were included for the analysis. The median age of 54 subjects was 66 yr and 48 were males. Calcified nodules and fibrotic changes were the most common forms of healed parenchymal pulmonary TB. Enlarged mediastinal lymph nodes (short diameter > 1 cm) were identified in 21 patients and positive mediastinal lymph nodes were identified using FDG-PET/CT in 19 patients. The overall sensitivity and specificity for mediastinal node metastasis were 60.0% and 69.2% with CT and 46.7% and 69.2% with FDG-PET/CT, respectively. In conclusion, the accuracy of nodal staging using CT or FDG-PET/CT might be low in lung cancer patients with parenchymal TB sequelae, because of inactive TB lymph nodes without viable TB bacilli.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalJournal of Korean Medical Science
Volume26
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1
Externally publishedYes

Fingerprint

Lung Neoplasms
Tuberculosis
Lymph Nodes
Tomography
Lung
Lymph Node Excision
Bacillus
Thorax
Neoplasm Metastasis
Sensitivity and Specificity
Positron Emission Tomography Computed Tomography

Keywords

  • Latent tuberculosis
  • Lung neoplasms
  • Lymph node
  • Mediastinum
  • Tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Impact of parenchymal tuberculosis sequelae on mediastinal lymph node staging in patients with lung cancer. / Lee, Seung Heon; Min, Joo Won; Lee, Chang Hoon; Park, Chang Min; Goo, Jin Mo; Chung, Doo Hyun; Kang, Chang Hyun; Kim, Young Tae; Kim, Young Whan; Han, Sung Koo; Shim, Young Soo; Yim, Jae Joon.

In: Journal of Korean Medical Science, Vol. 26, No. 1, 01.01.2011, p. 67-70.

Research output: Contribution to journalArticle

Lee, SH, Min, JW, Lee, CH, Park, CM, Goo, JM, Chung, DH, Kang, CH, Kim, YT, Kim, YW, Han, SK, Shim, YS & Yim, JJ 2011, 'Impact of parenchymal tuberculosis sequelae on mediastinal lymph node staging in patients with lung cancer', Journal of Korean Medical Science, vol. 26, no. 1, pp. 67-70. https://doi.org/10.3346/jkms.2011.26.1.67
Lee, Seung Heon ; Min, Joo Won ; Lee, Chang Hoon ; Park, Chang Min ; Goo, Jin Mo ; Chung, Doo Hyun ; Kang, Chang Hyun ; Kim, Young Tae ; Kim, Young Whan ; Han, Sung Koo ; Shim, Young Soo ; Yim, Jae Joon. / Impact of parenchymal tuberculosis sequelae on mediastinal lymph node staging in patients with lung cancer. In: Journal of Korean Medical Science. 2011 ; Vol. 26, No. 1. pp. 67-70.
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