Impact of postprocedure minimum stent area on long-term results following abciximab-coated stent implantation: An intravascular ultrasound analysis

Young Joon Hong, Myung Ho Jeong, Sun Ho Hwang, Nam Sik Yun, Sang Yup Lim, Sang Rok Lee, Seo Na Hong, Kye Hun Kim, Hyung Wook Park, Ju Han Kim, Weon Kim, Young Keun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang

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3 Citations (Scopus)

Abstract

Background: Smaller postprocedural minimum stent areas (MSA) measured by intravascular ultrasound (IVUS) have been associated with higher restenosis rates. Methods: This was a single-center, prospective, randomized trial and we assessed the predictive value of MSA for long-term patency and the incidence and extent of incomplete stent apposition (ISA) following abciximab-coated stent (n = 69) compared to bare metal stent (BMS) implantation (n = 69). All patients underwent IVUS follow-up at 6 months. Results: At follow-up coronary angiogram, the restenosis rate and late loss were 12%, 0.30 ± 0.24 mm in abciximab-coated stent group and 29%, 0.68 ± 0.36 mm in BMS group (p = 0.011, 0.010, respectively). At follow-up IVUS, intrastent lumen area was significantly larger and intrastent neointimal hyperplasia area was significantly smaller in abciximab-coated stent group than those in BMS group (5.9 ± 1.6 mm2 vs. 4.5 ± 1.7 mm2, p = 0.001, and 1.9 ± 1.5 mm2 vs. 3.3 ± 1.9 mm2, p < 0.001, respectively). Target lesion revascularization occurred in 9%, 0%, and 0% in abciximab-coated stent group and 19%, 4%, and 1% in BMS group in lesions with a MSA < 6.0 mm2, from 6 to 7.5 mm2, and > 7.5 mm2, respectively. Late-acquired ISA at follow-up was observed in 7 patients and there was no difference in the incidence of ISA between both groups [abciximab-coated stent: n = 3 (4%) vs. BMS: n = 4 (6%), p = 0.698]. Conclusion: Abciximab-coated stent reduced restenosis and had a considerably lower optimal MSA threshold compared to BMS and showed lower incidence of late-acquired ISA.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalInternational Journal of Cardiology
Volume123
Issue number1
DOIs
Publication statusPublished - 2007 Dec 15
Externally publishedYes

Keywords

  • Coronary artery diseases
  • Intravascular ultrasound
  • Platelets
  • Stents

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Hong, Y. J., Jeong, M. H., Hwang, S. H., Yun, N. S., Lim, S. Y., Lee, S. R., Hong, S. N., Kim, K. H., Park, H. W., Kim, J. H., Kim, W., Ahn, Y. K., Cho, J. G., Park, J. C., & Kang, J. C. (2007). Impact of postprocedure minimum stent area on long-term results following abciximab-coated stent implantation: An intravascular ultrasound analysis. International Journal of Cardiology, 123(1), 23-28. https://doi.org/10.1016/j.ijcard.2006.11.101