Impact of preceding flu-like illness on the serotype distribution of pneumococcal pneumonia

Research output: Contribution to journalArticle

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Abstract

Background: Even though the pathogenicity and invasiveness of pneumococcus largely depend on capsular types, the impact of serotypes on post-viral pneumococcal pneumonia is unknown. Methods and Findings: This study was performed to evaluate the impact of capsular serotypes on the development of pneumococcal pneumonia after preceding respiratory viral infections. Patients with a diagnosis of pneumococcal pneumonia were identified. Pneumonia patients were divided into two groups (post-viral pneumococcal pneumonia versus primary pneumococcal pneumonia), and then their pneumococcal serotypes were compared. Nine hundred and nineteen patients with pneumococcal pneumonia were identified during the study period, including 327 (35.6%) cases with post-viral pneumococcal pneumonia and 592 (64.4%) cases with primary pneumococcal pneumonia. Overall, serotypes 3 and 19A were the most prevalent, followed by serotypes 19F, 6A, and 11A/11E. Although relatively uncommon (33 cases, 3.6%), infrequently colonizing invasive serotypes (4, 5, 7F/7A, 8, 9V/9A, 12F, and 18C) were significantly associated with preceding respiratory viral infections (69.7%, P<,0.01). Multivariate analysis revealed several statistically significant risk factors for postviral pneumococcal pneumonia: immunodeficiency (OR 1.66; 95% CI, 1.10-2.53), chronic lung diseases (OR 1.43; 95% CI, 1.09-1.93) and ICI serotypes (OR 4.66; 95% CI, 2.07-10.47). Conclusions: Infrequently colonizing invasive serotypes would be more likely to cause pneumococcal pneumonia after preceding respiratory viral illness, particularly in patients with immunodeficiency or chronic lung diseases.

Original languageEnglish
Article numbere93477
JournalPLoS One
Volume9
Issue number4
DOIs
Publication statusPublished - 2014 Apr 1

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Pneumococcal Pneumonia
Pulmonary diseases
influenza
pneumonia
serotypes
viral pneumonia
Viral Pneumonia
immunosuppression
respiratory tract diseases
Virus Diseases
Respiratory Tract Infections
Lung Diseases
Chronic Disease
Serogroup
infection
multivariate analysis
Streptococcus pneumoniae
risk factors
pathogenicity
Virulence

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Impact of preceding flu-like illness on the serotype distribution of pneumococcal pneumonia. / Song, Joon-Young; Nahm, Moon H.; Cheong, Hee-Jin; Kim, Woo Joo.

In: PLoS One, Vol. 9, No. 4, e93477, 01.04.2014.

Research output: Contribution to journalArticle

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abstract = "Background: Even though the pathogenicity and invasiveness of pneumococcus largely depend on capsular types, the impact of serotypes on post-viral pneumococcal pneumonia is unknown. Methods and Findings: This study was performed to evaluate the impact of capsular serotypes on the development of pneumococcal pneumonia after preceding respiratory viral infections. Patients with a diagnosis of pneumococcal pneumonia were identified. Pneumonia patients were divided into two groups (post-viral pneumococcal pneumonia versus primary pneumococcal pneumonia), and then their pneumococcal serotypes were compared. Nine hundred and nineteen patients with pneumococcal pneumonia were identified during the study period, including 327 (35.6{\%}) cases with post-viral pneumococcal pneumonia and 592 (64.4{\%}) cases with primary pneumococcal pneumonia. Overall, serotypes 3 and 19A were the most prevalent, followed by serotypes 19F, 6A, and 11A/11E. Although relatively uncommon (33 cases, 3.6{\%}), infrequently colonizing invasive serotypes (4, 5, 7F/7A, 8, 9V/9A, 12F, and 18C) were significantly associated with preceding respiratory viral infections (69.7{\%}, P<,0.01). Multivariate analysis revealed several statistically significant risk factors for postviral pneumococcal pneumonia: immunodeficiency (OR 1.66; 95{\%} CI, 1.10-2.53), chronic lung diseases (OR 1.43; 95{\%} CI, 1.09-1.93) and ICI serotypes (OR 4.66; 95{\%} CI, 2.07-10.47). Conclusions: Infrequently colonizing invasive serotypes would be more likely to cause pneumococcal pneumonia after preceding respiratory viral illness, particularly in patients with immunodeficiency or chronic lung diseases.",
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