Impact of preinterventional arterial remodeling on in-stent neointimal hyperplasia and in-stent restenosis after coronary stent implantation - An intravascular ultrasound study

Young Joon Hong, Myung Ho Jeong, Dae Woo Hyun, Seung Ho Hur, Kwon Bae Kim, Weon Kim, Sang Yeob Lim, Sang Hyun Lee, Seo Na Hong, Kye Hoon Kim, Kyung Ho Yun, Dong Goo Kang, Yun Sang Lee, Hyung Wook Park, Ju Han Kim, Young Keun Ahn, Jeong Gwan Cho, Jong Chun Park, Jung Chaee Kang

Research output: Contribution to journalArticle

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Abstract

Background: Patterns of arterial remodeling during the course of plaque development have been shown to play an important role in both the progression of de novo atherosclerosis and in the restenotic process following coronary intervention. The aim of the present prospective study was to evaluate the effect of pre-interventional arterial remodeling on in-stent neointimal hyperplasia (NIH) and in-stent restenosis (ISR) after stenting. Methods and Results: Pre-interventional arterial remodeling was assessed in 85 native coronary lesions by using intravascular ultrasound (IVUS). The remodeling index (RI) was 1.09±0.20 in the positive remodeling (PR)/intermediate remodeling (IR) group and 0.84±0.12 in the negative remodeling (NR) group. The plaque plus media cross sectional area (P&M CSA) at pre-intervention and NIH CSA at follow-up in the minimal lumen CSA were significantly larger in the PR/IR group (9.2±2.9 mm2 vs 6.2±1.8 mm2, 3.3±1.2 mm2 vs 1.5±0.9 mm2; p=0.001, p=0.001, respectively). On 3-dimensional analysis of IVUS images at follow-up, the lumen volume was significantly smaller in the PR/IR group than that in the NR group (62±15 mm3 vs 75±20 mm3; p=0.001), and neointima hyperplasia volume was significantly larger in the PR/IR group than that in the NR group (46± 15 mm3 vs 26±10 mm3; p=0.001). A significant positive correlation was found between pre-interventional R1 and follow-up NIH CSA (r=0.25, p=0.022). The incidence of ISR and repeat intervention was significantly higher in the PR/IR group (30.8% vs 18.2%, 28.8% vs 15.2%; p=0.032, 0.035, respectively). Conclusion: Measuring pre-interventional arterial remodeling patterns by IVUS may be helpful to stratify lesions at high-risk of ISR.

Original languageEnglish
Pages (from-to)414-419
Number of pages6
JournalCirculation Journal
Volume69
Issue number4
DOIs
Publication statusPublished - 2005 Apr 1
Externally publishedYes

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Coronary Restenosis
Hyperplasia
Stents
Neointima
Atherosclerosis
Prospective Studies
Incidence

Keywords

  • Arterial remodeling
  • Restenosis
  • Stent

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Impact of preinterventional arterial remodeling on in-stent neointimal hyperplasia and in-stent restenosis after coronary stent implantation - An intravascular ultrasound study. / Hong, Young Joon; Jeong, Myung Ho; Hyun, Dae Woo; Hur, Seung Ho; Kim, Kwon Bae; Kim, Weon; Lim, Sang Yeob; Lee, Sang Hyun; Hong, Seo Na; Kim, Kye Hoon; Yun, Kyung Ho; Kang, Dong Goo; Lee, Yun Sang; Park, Hyung Wook; Kim, Ju Han; Ahn, Young Keun; Cho, Jeong Gwan; Park, Jong Chun; Kang, Jung Chaee.

In: Circulation Journal, Vol. 69, No. 4, 01.04.2005, p. 414-419.

Research output: Contribution to journalArticle

Hong, YJ, Jeong, MH, Hyun, DW, Hur, SH, Kim, KB, Kim, W, Lim, SY, Lee, SH, Hong, SN, Kim, KH, Yun, KH, Kang, DG, Lee, YS, Park, HW, Kim, JH, Ahn, YK, Cho, JG, Park, JC & Kang, JC 2005, 'Impact of preinterventional arterial remodeling on in-stent neointimal hyperplasia and in-stent restenosis after coronary stent implantation - An intravascular ultrasound study', Circulation Journal, vol. 69, no. 4, pp. 414-419. https://doi.org/10.1253/circj.69.414
Hong, Young Joon ; Jeong, Myung Ho ; Hyun, Dae Woo ; Hur, Seung Ho ; Kim, Kwon Bae ; Kim, Weon ; Lim, Sang Yeob ; Lee, Sang Hyun ; Hong, Seo Na ; Kim, Kye Hoon ; Yun, Kyung Ho ; Kang, Dong Goo ; Lee, Yun Sang ; Park, Hyung Wook ; Kim, Ju Han ; Ahn, Young Keun ; Cho, Jeong Gwan ; Park, Jong Chun ; Kang, Jung Chaee. / Impact of preinterventional arterial remodeling on in-stent neointimal hyperplasia and in-stent restenosis after coronary stent implantation - An intravascular ultrasound study. In: Circulation Journal. 2005 ; Vol. 69, No. 4. pp. 414-419.
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T1 - Impact of preinterventional arterial remodeling on in-stent neointimal hyperplasia and in-stent restenosis after coronary stent implantation - An intravascular ultrasound study

AU - Hong, Young Joon

AU - Jeong, Myung Ho

AU - Hyun, Dae Woo

AU - Hur, Seung Ho

AU - Kim, Kwon Bae

AU - Kim, Weon

AU - Lim, Sang Yeob

AU - Lee, Sang Hyun

AU - Hong, Seo Na

AU - Kim, Kye Hoon

AU - Yun, Kyung Ho

AU - Kang, Dong Goo

AU - Lee, Yun Sang

AU - Park, Hyung Wook

AU - Kim, Ju Han

AU - Ahn, Young Keun

AU - Cho, Jeong Gwan

AU - Park, Jong Chun

AU - Kang, Jung Chaee

PY - 2005/4/1

Y1 - 2005/4/1

N2 - Background: Patterns of arterial remodeling during the course of plaque development have been shown to play an important role in both the progression of de novo atherosclerosis and in the restenotic process following coronary intervention. The aim of the present prospective study was to evaluate the effect of pre-interventional arterial remodeling on in-stent neointimal hyperplasia (NIH) and in-stent restenosis (ISR) after stenting. Methods and Results: Pre-interventional arterial remodeling was assessed in 85 native coronary lesions by using intravascular ultrasound (IVUS). The remodeling index (RI) was 1.09±0.20 in the positive remodeling (PR)/intermediate remodeling (IR) group and 0.84±0.12 in the negative remodeling (NR) group. The plaque plus media cross sectional area (P&M CSA) at pre-intervention and NIH CSA at follow-up in the minimal lumen CSA were significantly larger in the PR/IR group (9.2±2.9 mm2 vs 6.2±1.8 mm2, 3.3±1.2 mm2 vs 1.5±0.9 mm2; p=0.001, p=0.001, respectively). On 3-dimensional analysis of IVUS images at follow-up, the lumen volume was significantly smaller in the PR/IR group than that in the NR group (62±15 mm3 vs 75±20 mm3; p=0.001), and neointima hyperplasia volume was significantly larger in the PR/IR group than that in the NR group (46± 15 mm3 vs 26±10 mm3; p=0.001). A significant positive correlation was found between pre-interventional R1 and follow-up NIH CSA (r=0.25, p=0.022). The incidence of ISR and repeat intervention was significantly higher in the PR/IR group (30.8% vs 18.2%, 28.8% vs 15.2%; p=0.032, 0.035, respectively). Conclusion: Measuring pre-interventional arterial remodeling patterns by IVUS may be helpful to stratify lesions at high-risk of ISR.

AB - Background: Patterns of arterial remodeling during the course of plaque development have been shown to play an important role in both the progression of de novo atherosclerosis and in the restenotic process following coronary intervention. The aim of the present prospective study was to evaluate the effect of pre-interventional arterial remodeling on in-stent neointimal hyperplasia (NIH) and in-stent restenosis (ISR) after stenting. Methods and Results: Pre-interventional arterial remodeling was assessed in 85 native coronary lesions by using intravascular ultrasound (IVUS). The remodeling index (RI) was 1.09±0.20 in the positive remodeling (PR)/intermediate remodeling (IR) group and 0.84±0.12 in the negative remodeling (NR) group. The plaque plus media cross sectional area (P&M CSA) at pre-intervention and NIH CSA at follow-up in the minimal lumen CSA were significantly larger in the PR/IR group (9.2±2.9 mm2 vs 6.2±1.8 mm2, 3.3±1.2 mm2 vs 1.5±0.9 mm2; p=0.001, p=0.001, respectively). On 3-dimensional analysis of IVUS images at follow-up, the lumen volume was significantly smaller in the PR/IR group than that in the NR group (62±15 mm3 vs 75±20 mm3; p=0.001), and neointima hyperplasia volume was significantly larger in the PR/IR group than that in the NR group (46± 15 mm3 vs 26±10 mm3; p=0.001). A significant positive correlation was found between pre-interventional R1 and follow-up NIH CSA (r=0.25, p=0.022). The incidence of ISR and repeat intervention was significantly higher in the PR/IR group (30.8% vs 18.2%, 28.8% vs 15.2%; p=0.032, 0.035, respectively). Conclusion: Measuring pre-interventional arterial remodeling patterns by IVUS may be helpful to stratify lesions at high-risk of ISR.

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KW - Restenosis

KW - Stent

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