Impact of preoperative thrombocytosis on prognosis after surgical treatment in pathological T1 and T2 renal cell carcinoma: Results of a multi-institutional comprehensive study

KORCC study group

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2 Citations (Scopus)

Abstract

Background: The prognostic significance of preoperative thrombocytosis (TC) in renal cell carcinoma (RCC) is not without some debate. The aim of the present multi-institutional study was to determine the association of preoperative TC with the clinicopathological features and prognosis of localized RCC patients who underwent surgery in a large cohort. Methods: A study involving 8 institutions, and 4,376 patients with pT1 and pT2 RCC from the Korean renal cell carcinoma (KORCC) database, was conducted. TC was defined as a platelet count ≥400,000/μL. Patients were divided into 2 groups based on the presence of preoperative TC. Clinicopathological variables and survival rates were compared between the 2 groups. Results: Out of the 4,376 patients in the study, 106 (2.4%) had preoperative TC. Compared to patients without TC, these patients had a lower body mass index. Additionally, these patients had more advanced stage tumors with a higher Fuhrman grade, and higher incidence of symptoms at the time of diagnosis. Kaplan-Meier curves revealed that patients with TC had a significantly lower rate of recurrencefree survival (RFS). Furthermore, a lower rate of overall survival (OS) was exhibited amongst patients with TC. Multivariate analysis revealed that TC was an independent prognostic factor in terms of the RFS and OS. Conclusions: TC appeared to be an important prognostic determinant in localized RCC. Furthermore, preoperative platelet count may be clinically useful for risk stratification of patients with surgically treated localized RCC.

Original languageEnglish
Pages (from-to)64449-64458
Number of pages10
JournalOncotarget
Volume8
Issue number38
DOIs
Publication statusPublished - 2017 Jan 1

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Thrombocytosis
Renal Cell Carcinoma
Therapeutics
Survival Rate
Platelet Count
Survival
Body Mass Index
Multivariate Analysis
Databases

Keywords

  • Prognosis
  • Renal cell carcinoma
  • Thrombocytosis

ASJC Scopus subject areas

  • Oncology

Cite this

@article{5a52b041120745ce86609b4f8fe40c64,
title = "Impact of preoperative thrombocytosis on prognosis after surgical treatment in pathological T1 and T2 renal cell carcinoma: Results of a multi-institutional comprehensive study",
abstract = "Background: The prognostic significance of preoperative thrombocytosis (TC) in renal cell carcinoma (RCC) is not without some debate. The aim of the present multi-institutional study was to determine the association of preoperative TC with the clinicopathological features and prognosis of localized RCC patients who underwent surgery in a large cohort. Methods: A study involving 8 institutions, and 4,376 patients with pT1 and pT2 RCC from the Korean renal cell carcinoma (KORCC) database, was conducted. TC was defined as a platelet count ≥400,000/μL. Patients were divided into 2 groups based on the presence of preoperative TC. Clinicopathological variables and survival rates were compared between the 2 groups. Results: Out of the 4,376 patients in the study, 106 (2.4{\%}) had preoperative TC. Compared to patients without TC, these patients had a lower body mass index. Additionally, these patients had more advanced stage tumors with a higher Fuhrman grade, and higher incidence of symptoms at the time of diagnosis. Kaplan-Meier curves revealed that patients with TC had a significantly lower rate of recurrencefree survival (RFS). Furthermore, a lower rate of overall survival (OS) was exhibited amongst patients with TC. Multivariate analysis revealed that TC was an independent prognostic factor in terms of the RFS and OS. Conclusions: TC appeared to be an important prognostic determinant in localized RCC. Furthermore, preoperative platelet count may be clinically useful for risk stratification of patients with surgically treated localized RCC.",
keywords = "Prognosis, Renal cell carcinoma, Thrombocytosis",
author = "{KORCC study group} and Ha, {Yun Sok} and Chung, {Jae Wook} and Chun, {So Young} and Choi, {Seock Hwan} and Lee, {Jun Nyung} and Kim, {Bum Soo} and Kim, {Hyun Tae} and Kim, {Tae Hwan} and Byun, {Seok Soo} and Hwang, {Eu Chang} and Kang, {Seok Ho} and Hong, {Sung Hoo} and Jinsoo Chung and Cheol Kwak and Kim, {Yong June} and Kwon, {Tae Gyun}",
year = "2017",
month = "1",
day = "1",
doi = "10.18632/oncotarget.16136",
language = "English",
volume = "8",
pages = "64449--64458",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "38",

}

TY - JOUR

T1 - Impact of preoperative thrombocytosis on prognosis after surgical treatment in pathological T1 and T2 renal cell carcinoma

T2 - Results of a multi-institutional comprehensive study

AU - KORCC study group

AU - Ha, Yun Sok

AU - Chung, Jae Wook

AU - Chun, So Young

AU - Choi, Seock Hwan

AU - Lee, Jun Nyung

AU - Kim, Bum Soo

AU - Kim, Hyun Tae

AU - Kim, Tae Hwan

AU - Byun, Seok Soo

AU - Hwang, Eu Chang

AU - Kang, Seok Ho

AU - Hong, Sung Hoo

AU - Chung, Jinsoo

AU - Kwak, Cheol

AU - Kim, Yong June

AU - Kwon, Tae Gyun

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Background: The prognostic significance of preoperative thrombocytosis (TC) in renal cell carcinoma (RCC) is not without some debate. The aim of the present multi-institutional study was to determine the association of preoperative TC with the clinicopathological features and prognosis of localized RCC patients who underwent surgery in a large cohort. Methods: A study involving 8 institutions, and 4,376 patients with pT1 and pT2 RCC from the Korean renal cell carcinoma (KORCC) database, was conducted. TC was defined as a platelet count ≥400,000/μL. Patients were divided into 2 groups based on the presence of preoperative TC. Clinicopathological variables and survival rates were compared between the 2 groups. Results: Out of the 4,376 patients in the study, 106 (2.4%) had preoperative TC. Compared to patients without TC, these patients had a lower body mass index. Additionally, these patients had more advanced stage tumors with a higher Fuhrman grade, and higher incidence of symptoms at the time of diagnosis. Kaplan-Meier curves revealed that patients with TC had a significantly lower rate of recurrencefree survival (RFS). Furthermore, a lower rate of overall survival (OS) was exhibited amongst patients with TC. Multivariate analysis revealed that TC was an independent prognostic factor in terms of the RFS and OS. Conclusions: TC appeared to be an important prognostic determinant in localized RCC. Furthermore, preoperative platelet count may be clinically useful for risk stratification of patients with surgically treated localized RCC.

AB - Background: The prognostic significance of preoperative thrombocytosis (TC) in renal cell carcinoma (RCC) is not without some debate. The aim of the present multi-institutional study was to determine the association of preoperative TC with the clinicopathological features and prognosis of localized RCC patients who underwent surgery in a large cohort. Methods: A study involving 8 institutions, and 4,376 patients with pT1 and pT2 RCC from the Korean renal cell carcinoma (KORCC) database, was conducted. TC was defined as a platelet count ≥400,000/μL. Patients were divided into 2 groups based on the presence of preoperative TC. Clinicopathological variables and survival rates were compared between the 2 groups. Results: Out of the 4,376 patients in the study, 106 (2.4%) had preoperative TC. Compared to patients without TC, these patients had a lower body mass index. Additionally, these patients had more advanced stage tumors with a higher Fuhrman grade, and higher incidence of symptoms at the time of diagnosis. Kaplan-Meier curves revealed that patients with TC had a significantly lower rate of recurrencefree survival (RFS). Furthermore, a lower rate of overall survival (OS) was exhibited amongst patients with TC. Multivariate analysis revealed that TC was an independent prognostic factor in terms of the RFS and OS. Conclusions: TC appeared to be an important prognostic determinant in localized RCC. Furthermore, preoperative platelet count may be clinically useful for risk stratification of patients with surgically treated localized RCC.

KW - Prognosis

KW - Renal cell carcinoma

KW - Thrombocytosis

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U2 - 10.18632/oncotarget.16136

DO - 10.18632/oncotarget.16136

M3 - Article

AN - SCOPUS:85029911388

VL - 8

SP - 64449

EP - 64458

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 38

ER -