Impact of preoperative visceral fat proportion on type 2 diabetes in patients with low body mass index after gastrectomy

Min Jeong Park, Dong Hyeok Kim, Beomjin Park, Sungeun Kim, Sungsoo Park, Raul J. Rosenthal

Research output: Contribution to journalArticle

Abstract

Background Metabolic surgery is an effective option for treatment of type 2 diabetes. Although body mass index (BMI) has several limitations in differentiating the metabolic risks of the same weight of muscle and fat, it is used as the basis of indication for metabolic surgery. Objectives Since visceral fat is highly associated with metabolic disease, we evaluated the effectiveness of visceral fat proportion (VFP) for predicting metabolic risk preoperatively. Setting University hospital. Methods Fifty-two type 2 diabetes patients with BMI≤35 kg/cm2 who underwent gastrectomy for gastric cancer were included. Pre- and postoperative VFPs were measured using abdominal computed tomography. Multivariate logistic regression analysis was performed to estimate the effect of VFP on type 2 diabetes. Receiver operating curve analysis was used to estimate the effectiveness of VFP as a predictor of type 2 diabetes improvement. Results Thirty-three of the 52 patients (63%) showed improved type 2 diabetes postoperatively. Low preoperative VFP (odds ratio [OR] =.913; 95% confidence interval [CI] =.835–.999; P =.048) and low glycated hemoglobin level (OR =.357; 95% CI =.172–.742; P =.006) were associated with type 2 diabetes improvement 2 years after gastrectomy. The area under the curve was 70.2%, indicating moderate accuracy. Conclusions Preoperative VFP might be a reasonable predictive factor for type 2 diabetes improvement after gastrectomy for patients with a BMI≤35 kg/cm2. High-quality studies of visceral fat for metabolic function are needed in the future.

Original languageEnglish
Pages (from-to)1361-1368
Number of pages8
JournalSurgery for Obesity and Related Diseases
Volume13
Issue number8
DOIs
Publication statusPublished - 2017 Aug 1

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Intra-Abdominal Fat
Gastrectomy
Type 2 Diabetes Mellitus
Body Mass Index
Bariatric Surgery
Odds Ratio
Confidence Intervals
Metabolic Diseases
Glycosylated Hemoglobin A
Stomach Neoplasms
Area Under Curve
Logistic Models
Fats
Tomography
Regression Analysis
Weights and Measures
Muscles

Keywords

  • Computed tomography
  • Gastrectomy
  • Intra-abdominal fat
  • Type 2 diabetes

ASJC Scopus subject areas

  • Surgery

Cite this

Impact of preoperative visceral fat proportion on type 2 diabetes in patients with low body mass index after gastrectomy. / Park, Min Jeong; Kim, Dong Hyeok; Park, Beomjin; Kim, Sungeun; Park, Sungsoo; Rosenthal, Raul J.

In: Surgery for Obesity and Related Diseases, Vol. 13, No. 8, 01.08.2017, p. 1361-1368.

Research output: Contribution to journalArticle

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abstract = "Background Metabolic surgery is an effective option for treatment of type 2 diabetes. Although body mass index (BMI) has several limitations in differentiating the metabolic risks of the same weight of muscle and fat, it is used as the basis of indication for metabolic surgery. Objectives Since visceral fat is highly associated with metabolic disease, we evaluated the effectiveness of visceral fat proportion (VFP) for predicting metabolic risk preoperatively. Setting University hospital. Methods Fifty-two type 2 diabetes patients with BMI≤35 kg/cm2 who underwent gastrectomy for gastric cancer were included. Pre- and postoperative VFPs were measured using abdominal computed tomography. Multivariate logistic regression analysis was performed to estimate the effect of VFP on type 2 diabetes. Receiver operating curve analysis was used to estimate the effectiveness of VFP as a predictor of type 2 diabetes improvement. Results Thirty-three of the 52 patients (63{\%}) showed improved type 2 diabetes postoperatively. Low preoperative VFP (odds ratio [OR] =.913; 95{\%} confidence interval [CI] =.835–.999; P =.048) and low glycated hemoglobin level (OR =.357; 95{\%} CI =.172–.742; P =.006) were associated with type 2 diabetes improvement 2 years after gastrectomy. The area under the curve was 70.2{\%}, indicating moderate accuracy. Conclusions Preoperative VFP might be a reasonable predictive factor for type 2 diabetes improvement after gastrectomy for patients with a BMI≤35 kg/cm2. High-quality studies of visceral fat for metabolic function are needed in the future.",
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N2 - Background Metabolic surgery is an effective option for treatment of type 2 diabetes. Although body mass index (BMI) has several limitations in differentiating the metabolic risks of the same weight of muscle and fat, it is used as the basis of indication for metabolic surgery. Objectives Since visceral fat is highly associated with metabolic disease, we evaluated the effectiveness of visceral fat proportion (VFP) for predicting metabolic risk preoperatively. Setting University hospital. Methods Fifty-two type 2 diabetes patients with BMI≤35 kg/cm2 who underwent gastrectomy for gastric cancer were included. Pre- and postoperative VFPs were measured using abdominal computed tomography. Multivariate logistic regression analysis was performed to estimate the effect of VFP on type 2 diabetes. Receiver operating curve analysis was used to estimate the effectiveness of VFP as a predictor of type 2 diabetes improvement. Results Thirty-three of the 52 patients (63%) showed improved type 2 diabetes postoperatively. Low preoperative VFP (odds ratio [OR] =.913; 95% confidence interval [CI] =.835–.999; P =.048) and low glycated hemoglobin level (OR =.357; 95% CI =.172–.742; P =.006) were associated with type 2 diabetes improvement 2 years after gastrectomy. The area under the curve was 70.2%, indicating moderate accuracy. Conclusions Preoperative VFP might be a reasonable predictive factor for type 2 diabetes improvement after gastrectomy for patients with a BMI≤35 kg/cm2. High-quality studies of visceral fat for metabolic function are needed in the future.

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