Impact of sirolimus-eluting stents on outcomes of patients treated for acute myocardial infarction by primary angioplasty

Edouard Cheneau, Seung-Woon Rha, Pramod K. Kuchulakanti, Eugenio Stabile, Timothy Kinnaird, Rebecca Torguson, Augusto D. Pichard, Lowell F. Satler, Kenneth M. Kent, Ron Waksman

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Sirolimus-eluting stents (SESs) are currently being used in patients undergoing percutaneous coronary intervention (PCI). SESs have not been evaluated in the treatment of acute myocardial infarction by primary angioplasty. We report our initial experience with SESs implanted during primary angioplasty. One hundred and three patients were treated within 12 hr after onset of acute myocardial infarction (AMI) with primary angioplasty and SES implantation. Those patients were compared to 504 patients treated with bare metal stents (BMSs). Angiographic success (TIMI flow grade 3 and residual stenosis < 50%) was completed in 98% of patients with SESs and no subacute stent thrombosis was reported. Inhospital outcomes were similar in the SES and BMS groups. At 6 months, major cardiac events were less frequent in the SES group than in the BMS group (9% vs. 24%, respectively; P < 0.001), driven by a lesser need for repeat revascularization with SESs (1% vs. 10.3% with BMSs; P = 0.014). Mortality at 6 months was 7% with SESs and 11% with BMSs (P = 0.14). SESs are safe and effective for the treatment of AMI by primary angioplasty. As compared to BMSs, SESs improve long-term outcome after AMI, mainly by reducing the need for repeat revascularization.

Original languageEnglish
Pages (from-to)469-472
Number of pages4
JournalCatheterization and Cardiovascular Interventions
Issue number4
Publication statusPublished - 2005 Aug 1
Externally publishedYes



  • Drug-eluting stent
  • Myocardial infarction
  • Percutaneous coronary intervention

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Cheneau, E., Rha, S-W., Kuchulakanti, P. K., Stabile, E., Kinnaird, T., Torguson, R., Pichard, A. D., Satler, L. F., Kent, K. M., & Waksman, R. (2005). Impact of sirolimus-eluting stents on outcomes of patients treated for acute myocardial infarction by primary angioplasty. Catheterization and Cardiovascular Interventions, 65(4), 469-472.