Impact of skip metastasis in gastric cancer

Sungsoo Park, Je Seock Ryu, Byung Wook Min, Wan-Bae Kim, Seung Joo Kim, Chong Suk Kim, Young Jae Mok

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Several studies have shown the features of skip metastasis in other cancers besides gastric cancer. Since minimally invasive surgery has been applied to gastric cancer, the concerns and awareness of skip metastasis have grown in the medical community. We conducted the present retrospective study to reveal the clinicopathological characteristics of patients with skip metastasis. We also wished to clarify the clinical impact of skip metastasis for gastric cancer. Methods: Five hundred and eighty-nine patients having lymphatic metastases were enrolled in the present study. Among them, 266 patients had positive nodes extending into the N2 group. We divided these patients into the skip positive (+) and the skip negative (-) group, and we comparatively analysed clinicopathological factors and calculated the survival probabilities for the two groups. Results: The skip (+) and skip (-) groups involved 14 (5.3%) and 252 (94.7%) patients, respectively. Of all the investigated factors, a significant difference between two groups was observed only in the total number of retrieved nodes. Stations of skip nodes were along left gastric (7), anterior common hepatic (8a), celiac (9), splenic (11) artery and right paracardial nodes (1). The survival curves calculated in the present study did not show any statistical differences between the groups. Conclusions: Due to problems of skip metastasis in gastric cancer, D2 lymph node dissection should be performed until sentinel node detection is feasible and reliable. The potential risk from skip metastasis is not great and skip metastasis itself should not be a major consideration in therapeutic decisions.

Original languageEnglish
Pages (from-to)645-649
Number of pages5
JournalANZ Journal of Surgery
Volume75
Issue number8
DOIs
Publication statusPublished - 2005 Aug 1

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Stomach Neoplasms
Neoplasm Metastasis
Lymphatic Metastasis
Splenic Artery
Minimally Invasive Surgical Procedures
Survival
Lymph Node Excision
Abdomen
Stomach
Retrospective Studies
Liver

Keywords

  • Gastric cancer
  • Lymph node
  • Skip metastasis

ASJC Scopus subject areas

  • Surgery

Cite this

Impact of skip metastasis in gastric cancer. / Park, Sungsoo; Ryu, Je Seock; Min, Byung Wook; Kim, Wan-Bae; Kim, Seung Joo; Kim, Chong Suk; Mok, Young Jae.

In: ANZ Journal of Surgery, Vol. 75, No. 8, 01.08.2005, p. 645-649.

Research output: Contribution to journalArticle

Park, Sungsoo ; Ryu, Je Seock ; Min, Byung Wook ; Kim, Wan-Bae ; Kim, Seung Joo ; Kim, Chong Suk ; Mok, Young Jae. / Impact of skip metastasis in gastric cancer. In: ANZ Journal of Surgery. 2005 ; Vol. 75, No. 8. pp. 645-649.
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