Impact of Sleep-Disordered Breathing on Functional Outcomes in Ischemic Stroke: A Cardiopulmonary Coupling Analysis

Dong Oh Kang, Chi Kyung Kim, Yoonjee Park, Won Young Jang, Woohyeun Kim, Jah Yeon Choi, Seung Young Roh, Cheol Ung Choi, Eung Ju Kim, Seung Woon Rha, Chang Gyu Park, Hong Seog Seo, Kyungmi Oh, Jin Oh Na

Research output: Contribution to journalArticle

Abstract

Background and Purpose: Cardiopulmonary coupling (CPC) analysis is an easily assessable method to evaluate sleep-disordered breathing (SDB); however, its prognostic impact in patients with acute ischemic stroke needs to be investigated. We performed a CPC analysis using Holter monitoring at the early stage of noncardioembolic ischemic stroke to investigate the prognostic effect of SDB on functional impairment at the 3-month follow-up. Methods: A total 615 patients with acute noncardioembolic ischemic stroke who underwent Holter monitoring within 30 days of stroke onset were enrolled from a multicenter, prospective, all-comer cohort. CPC analysis was conducted, and SDB was defined by the presence of narrow-band coupling during sleep time. We investigated the association between SDB and functional impairment at 3 months as measured by the modified Rankin Scale. Result: Narrow-band coupling was present in 191 (31.1%) of 615 patients (mean age 64.5±12.6 years). The narrow-band group showed a significantly higher rate of severe functional impairment (modified Rankin Scale score >2; 45.5% versus 12.9%, P<0.001) and persistent disability (Δmodified Rankin Scale score ≤0; 53.9% versus 39.8%, P<0.001) at the 3-month follow-up. In multivariate analysis, narrow-band coupling was an independent predictor of higher risk of severe and persistent functional impairment at 3 months (odds ratio, 3.98 [95% CI, 2.34-6.78]; P<0.001; and odds ratio, 1.81 [95% CI, 1.23-2.66]; P<0.001, respectively). The results remained consistent after propensity-score matched analysis with 157 patient pairs (C-statistic=0.770). Conclusions: SDB assessed by CPC analysis at the early stage of ischemic stroke could predict severe and prolonged functional impairment at 3 months. CPC analysis using Holter monitoring can help predicting functional impairment in acute ischemic stroke.

Original languageEnglish
Pages (from-to)2188-2196
Number of pages9
JournalStroke
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • cerebral infarction
  • electrocardiography
  • follow-up
  • odds ratio
  • recovery of function
  • sleep
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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  • Cite this

    Kang, D. O., Kim, C. K., Park, Y., Jang, W. Y., Kim, W., Choi, J. Y., Roh, S. Y., Choi, C. U., Kim, E. J., Rha, S. W., Park, C. G., Seo, H. S., Oh, K., & Na, J. O. (Accepted/In press). Impact of Sleep-Disordered Breathing on Functional Outcomes in Ischemic Stroke: A Cardiopulmonary Coupling Analysis. Stroke, 2188-2196. https://doi.org/10.1161/STROKEAHA.119.028730