Impact of smoking cessation on the risk of subarachnoid haemorrhage: A nationwide multicentre case control study

Chi Kyung Kim, Beom Joon Kim, Wi Sun Ryu, Seung Hoon Lee, Byung Woo Yoon

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and purpose: Subarachnoid haemorrhage (SAH) is the most devastating cerebrovascular disease. Cigarette smoking is one of the established risk factors for SAH, but the risk of SAH has not been properly elucidated in relation to smoking cessation. Methods: We performed a nationwide multicentre case control study involving 33 hospitals in Korea. A total of 426 SAH cases and 426 age and sex matched controls were enrolled. We obtained detailed information on lifestyle, medical history and, in particular, smoking habits from participants using structured questionnaires. Results: 148 SAH patients (37.4%) were current smokers compared with 103 (24.2%) controls, giving an adjusted OR of 2.84 (95% CI, 1.63 to 4.97) after controlling for possible confounders. Based on cumulative dose of smoking (pack years), the risk of SAH was found to increase in a dose-responsive fashion. Smoking cessation (≥5 years) caused a reduction in SAH to 59% (p<0.05). However, participants with a history of heavy smoking ($20 cigarettes per day) had a 2.3 times increased risk of SAH compared with participants who had never smoked (p<0.05). Conclusions: We have demonstrated that cigarette smoking increases the risk of SAH, but smoking cessation decreases the risk in a time dependent manner, although this beneficial effect may be diminished in previous heavy smokers. To forestall tragic SAH events, our results call for more global and vigorous efforts for people to stop smoking.

Original languageEnglish
Pages (from-to)1100-1103
Number of pages4
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume83
Issue number11
DOIs
Publication statusPublished - 2012 Nov

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

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