Impact of smoking status on clinical outcomes after successful chronic total occlusion intervention: Korean national registry of CTO intervention

Min Ho Lee, Jin Joo Park, Chang Hwan Yoon, Myung Jin Cha, Sang Don Park, Il Young Oh, Jung Won Suh, Young Seok Cho, Tae Jin Youn, Seung Woon Rha, Cheol Woong Yu, Hyeon Cheol Gwon, Yangsoo Jang, Hyo Soo Kim, In Ho Chae, Dong Ju Choi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: We sought to evaluate the effect of cigarette smoking on long-term outcomes after successful percutaneous coronary intervention for chronic total occlusion (CTO) lesions. Background: Cigarette smoking promotes the progression of atherosclerosis but enhances the antiplatelet effect of clopidogrel. Methods: The Korea National Registry of CTO Intervention included 2,167 patients with CTO lesions from 26 centers who were successfully revascularized with drug-eluting stents from 2007 to 2009. Thrombotic events were defined as the composite of cardiac death, nonfatal myocardial infarction, and stent thrombosis. Results: Current-smokers had more favorable baseline characteristics such as a younger age and lower prevalence of hypertension and diabetes mellitus. At 1 year, current-smokers had a significantly lower thrombotic event rate (1.1% vs. 2.7%, P=0.034), but a significantly higher target vessel revascularization (TVR) rate (7.2% vs. 4.2%, P=0.017) compared with never-smokers. After adjustment, current-smoking was independently associated with a 72% decreased risk for thrombotic events, and 73% increased risk for TVR. Conclusions: In patients with a revascularized CTO lesion, cigarette smoking is associated with fewer thrombotic events but with a higher incidence of TVR. Patients with CTO may benefit from smoking cessation to reduce TVR in conjunction with the use of new more potent antiplatelet agents whose effect is independent of cigarette smoking to improve thrombotic events.

Original languageEnglish
JournalCatheterization and Cardiovascular Interventions
DOIs
Publication statusAccepted/In press - 2015

Keywords

  • Chronic total occlusions
  • Outcomes
  • Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

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    Lee, M. H., Park, J. J., Yoon, C. H., Cha, M. J., Park, S. D., Oh, I. Y., Suh, J. W., Cho, Y. S., Youn, T. J., Rha, S. W., Yu, C. W., Gwon, H. C., Jang, Y., Kim, H. S., Chae, I. H., & Choi, D. J. (Accepted/In press). Impact of smoking status on clinical outcomes after successful chronic total occlusion intervention: Korean national registry of CTO intervention. Catheterization and Cardiovascular Interventions. https://doi.org/10.1002/ccd.26167