Impact of statin usage patterns on outcomes after percutaneous coronary intervention in acute myocardial infarction: Korea Working Group on Myocardial Infarction registry (KorMI) study

Chan Hee Lee, Sang Hee Lee, Jong Seon Park, Young Jo Kim, Kee Sik Kim, Shung Chull Chae, Hyo Soo Kim, Dong Ju Choi, Myeong Chan Cho, Seung-Woon Rha, Myung Ho Jeong

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The benefit of statin use after acute ST-segment elevation myocardial infarction (STEMI) has been well established, however, the influence of the timing of statin administration has not been elucidated. The objective of this study focused on early clinical outcomes after percutaneous coronary intervention (PCI). Methods: This analysis of the Korea Working Group on Myocardial Infarction registry (KorMI) study included 3,584 STEMI patients (mean age, 63 ± 13 years; male, 2,684, 74.9%) undergoing PCI from January 2008 to June 2009. Rates of major adverse cardiac events (MACE: all-cause death, recurrent MI, and target lesion revascularization) were compared among patients grouped according to statin therapy timing: I, both during and after hospitalization (n = 2,653, 74%); II, only during hospitalization (n = 309, 8.6%); III, only after discharge (n = 157, 4.4%); and IV, no statin therapy (n = 465, 13%). Mean follow-up duration was 234 ± 113 days. Results: Multivariate factors of statin use during hospitalization included prior statin use, multiple diseased vessels, final thrombolysis in myocardial infarction flow grade III, and low-density lipoprotein cholesterol level. At 6-month follow-up, groups III and IV had the highest MACE rates (2.3%, 3.9%, 5.1%, and 4.9% for groups I-IV, respectively, P = 0.004). After adjusting for confounders, groups II-IV had a higher MACE risk than group I [hazard ratio (HR): 3.20, 95% confidence interval (95%CI): 1.31-7.86, P = 0.011; HR: 3.84, 95%CI: 1.47-10.02, P = 0.006; and HR: 3.17, 95%CI: 1.59-6.40, P = 0.001; respectively]. Conclusions: This study, based on the national registry database, shows early and continuous statin therapy improvs early outcomes of STEMI patients after PCI in real-world clinical practice.

Original languageEnglish
Pages (from-to)93-99
Number of pages7
JournalJournal of Geriatric Cardiology
Volume11
Issue number2
DOIs
Publication statusPublished - 2014 Jan 1

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Geriatrics and Gerontology

Fingerprint Dive into the research topics of 'Impact of statin usage patterns on outcomes after percutaneous coronary intervention in acute myocardial infarction: Korea Working Group on Myocardial Infarction registry (KorMI) study'. Together they form a unique fingerprint.

  • Cite this