TY - JOUR
T1 - Impact of stent designs of second-generation drug-eluting stents on long-term outcomes in coronary bifurcation lesions
AU - Jang, Woo Jin
AU - Chun, Woo Jung
AU - Park, Ik Hyun
AU - Choi, Ki Hong
AU - Song, Young Bin
AU - Koo, Bon Kwon
AU - Doh, Joon Hyung
AU - Hong, Soon Jun
AU - Nam, Chang Wook
AU - Gwon, Hyeon Cheol
N1 - Funding Information:
We thank Yong Hwan Park, MD, Ju Hyeon Oh, MD, Joo‐Yong Hahn, MD, Seung‐Hyuk Choi, MD, Hyo‐Soo Kim, MD, Seung‐Ho Hur, MD, Seung Hwan Han, MD, Seung‐Woon Rha, MD, In‐Ho Chae, MD, Jin‐Ok Jeong, MD, Jung Ho Heo, MD, Junghan Yoon, MD, Do‐Sun Lim, MD, Jong‐Seon Park, MD, Myeong‐Ki Hong, MD, Kwang Soo Cha, MD, Doo‐Il Kim, MD, Sang Yeub Lee, MD, Kiyuk Chang, MD, Byung‐Hee Hwang, MD, So‐Yeon Choi, MD, and Myung Ho Jeong, MD for collection, design, analysis, or interpretation of data. We also thank Jin‐Seob Kim, MD, MPH for his statistical support. This work was supported by Korean Bifurcation Club and Korean Society of Interventional Cardiology.
Publisher Copyright:
© 2020 Wiley Periodicals LLC.
PY - 2021/9
Y1 - 2021/9
N2 - Objectives: We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background: Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods: Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group, n = 514), platinum chromium everolimus-eluting stent (PtCr-EES group, n = 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group, n = 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group, n = 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results: For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group, p =.434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively, p =.554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (p for interaction =.691). Conclusion: There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.
AB - Objectives: We compared the long-term clinical outcomes of four different types of second-generation drug-eluting stents (DESs) in coronary bifurcation lesions. Background: Clinical outcomes of different designs of second-generation DESs are not well known in bifurcation lesions. Methods: Patients who underwent percutaneous coronary intervention with second-generation DESs for coronary bifurcation lesion were enrolled from 21 centers in South Korea. A total of 2,526 patients was evaluated and divided into four treatment groups according to DES type: bioabsorbable polymer biolimus-eluting stent (BP-BES group, n = 514), platinum chromium everolimus-eluting stent (PtCr-EES group, n = 473), cobalt nickel zotarolimus-eluting stent (CoNi-ZES group, n = 736), or cobalt chromium everolimus-eluting stent (CoCr-EES group, n = 803). Primary outcome was target lesion failure (TLF, defined as a composite of cardiac death, target vessel myocardial infarction, or target lesion revascularization). Inverse probability of treatment weighting (IPTW) was performed to reduce selection bias and potential confounding factors. Results: For 5 years of follow-up, the rates of TLF among the four DES groups were not significantly different (6.2% for BP-BES group, 8.2% for PtCr-EES group, 6.5% for CoNi-ZES group, and 8.6% for CoCr-EES group, p =.434). The results were consistent after IPTW adjustment (6.8, 8.4, 6.0, and 7.5%, respectively, p =.554). In subgroup analysis, the similarity of long-term outcomes among the four different types of second-generation DES was consistent across subgroups regardless of side branch treatment (p for interaction =.691). Conclusion: There seems to be no significant difference in long-term clinical outcomes among patients who received different types of second-generation DES for coronary bifurcation lesion.
KW - coronary bifurcation lesion
KW - percutaneous coronary intervention
KW - second-generation drug-eluting stent
UR - http://www.scopus.com/inward/record.url?scp=85088805892&partnerID=8YFLogxK
U2 - 10.1002/ccd.29137
DO - 10.1002/ccd.29137
M3 - Article
AN - SCOPUS:85088805892
VL - 98
SP - 458
EP - 467
JO - Catheterization and Cardiovascular Interventions
JF - Catheterization and Cardiovascular Interventions
SN - 1522-1946
IS - 3
ER -