Impact of the Duration and Degree of Hypertension and Body Weight on New-Onset Atrial Fibrillation: A Nationwide Population-Based Study

Yun Gi Kim, Kyung Do Han, Jong Il Choi, Ki Yung Boo, Do Young Kim, Suk Kyu Oh, Kwang No Lee, Jaemin Shim, Jin Seok Kim, Young Hoon Kim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Hypertension and obesity are known risk factors for atrial fibrillation (AF). However, it is unclear whether uncontrolled, long-standing hypertension has a particularly profound effect on AF. Because they have a similar underlying pathophysiology, hypertension and obesity could act synergistically in the context of AF. We evaluated how various stages of hypertension and body weight status affect new-onset AF. We analyzed a total of 9 797 418 participants who underwent a national health checkup. Hypertension was classified into 5 stages: nonhypertension, prehypertension, hypertension without medication, hypertension with medication <5 years, and hypertension with medication ≥5 years. The participants were also stratified based on body mass index and waist circumference. During the 80 130 161 person×years follow-up, a total of 196 136 new-onset AF cases occurred. The incidence of new-onset AF gradually increased among the 5 stages of hypertension: the adjusted hazard ratio for each group was 1 (reference), 1.145, 1.390, 1.853, and 2.344 for each stage of hypertension. A graded escalation in the risk of new-onset AF was also observed in response to increased systolic and diastolic blood pressure. The incidence of new-onset AF correlated with body mass index and waist circumference, with obese people having a higher risk than others. Hypertension and obesity acted synergistically: obese people with hypertension on medication ≥5 years had the highest risk of AF. In conclusion, the degree and duration of hypertension, as well as the presence of hypertension, were important factors for new-onset AF. Body weight status was significantly associated with new-onset AF and acted synergistically with hypertension.

Original languageEnglish
Pages (from-to)e45-e51
JournalHypertension (Dallas, Tex. : 1979)
Volume74
Issue number5
DOIs
Publication statusPublished - 2019 Nov 1

Keywords

  • atrial fibrillation
  • body weight
  • obesity
  • risk factor
  • waist circumference

ASJC Scopus subject areas

  • Internal Medicine

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