Impact of the glucocorticoid receptor Bcl i polymorphism on reward expectancy and prediction error related ventral striatal reactivity in depressed and healthy individuals

Byung-Joo Ham, Tsafrir Greenberg, Henry W. Chase, Mary L. Phillips

Research output: Contribution to journalArticle

1 Citation (Scopus)


There is evidence that reward-related neural reactivity is altered in depressive disorders. Glucocorticoids influence dopaminergic transmission, which is widely implicated in reward processing. However, no studies have examined the effect of glucocorticoid receptor gene polymorphisms on reward-related neural reactivity in depressed or healthy individuals. Fifty-nine depressed individuals with major depressive disorder (n=33) or bipolar disorder (n=26), and 32 healthy individuals were genotyped for the glucocorticoid receptor BclI G/C polymorphism, and underwent functional magnetic resonance imaging during a monetary reward task. We examined the effect of the glucocorticoid receptor BclI G/C polymorphism on reward expectancy (RE; expected outcome value) and prediction error (PE; discrepancy between expected and actual outcome) related ventral striatal reactivity. There was a significant interaction between reward condition and BclI genotype (p=0.007). C-allele carriers showed higher PE than RE-related right ventral striatal reactivity (p

Original languageEnglish
Pages (from-to)48-55
Number of pages8
JournalJournal of Psychopharmacology
Issue number1
Publication statusPublished - 2016 Jan 1



  • Depression
  • fMRI
  • glucocorticoid
  • polymorphism
  • reward
  • striatum

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Psychiatry and Mental health

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