Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study

The Korean Sarcopenic Obesity Study (KSOS)

Tae Nyun Kim, Man Sik Park, Ja Young Ryu, Hae Yoon Choi, Ho Cheol Hong, Hye-Jin Yoo, Hyun Joo Kang, Wook Song, Seok Won Park, Sei-Hyun Baik, Anne B. Newman, Kyung Mook Choi

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objectives: Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. Methods: We observed changes in anthropometric and body composition data during a follow-up period of 27.6±2.8 months in 379 Korean men and women (mean age 51.9±14.6 years) from the Korean Sarcopenic Obesity Study (KSOS). Appendicular lean soft tissue (ALST) mass was calculated using dual-energy X-ray absorptiometry, and visceral fat area (VFA) was measured using computed tomography at baseline and follow-up examination. Results: ALST mass significantly decreased, whereas trunk and total fat mass increased in both men and women despite no significant change in weight and body mass index. In particular, women with visceral obesity at baseline had a greater decrease in ALST mass than those without visceral obesity (P=0.001). In multiple linear regression analysis, baseline VFA was an independent negative predictor of the changes in ALST after adjusting for confounding factors including age, gender, life style and body composition parameters, insulin resistance, high sensitivity C-reactive protein and vitamin D levels (P=0.001), whereas the association between baseline ALST mass and changes in VFA was not statistically significant (P=0.555). Conclusions: This longitudinal study showed that visceral obesity was associated with future loss of skeletal muscle mass in Korean adults. These results may provide novel insight into sarcopenic obesity in an aging society.

Original languageEnglish
Article numbere115407
JournalPLoS One
Volume9
Issue number12
DOIs
Publication statusPublished - 2014 Dec 17

Fingerprint

visceral fat
Intra-Abdominal Fat
cohort studies
Abdominal Obesity
Muscle
skeletal muscle
Skeletal Muscle
obesity
Cohort Studies
Obesity
Fats
Prospective Studies
Tissue
Body Composition
Sarcopenia
body composition
Age Factors
Photon Absorptiometry
sarcopenia
Chemical analysis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study : The Korean Sarcopenic Obesity Study (KSOS). / Kim, Tae Nyun; Park, Man Sik; Ryu, Ja Young; Choi, Hae Yoon; Hong, Ho Cheol; Yoo, Hye-Jin; Kang, Hyun Joo; Song, Wook; Park, Seok Won; Baik, Sei-Hyun; Newman, Anne B.; Choi, Kyung Mook.

In: PLoS One, Vol. 9, No. 12, e115407, 17.12.2014.

Research output: Contribution to journalArticle

Kim, Tae Nyun ; Park, Man Sik ; Ryu, Ja Young ; Choi, Hae Yoon ; Hong, Ho Cheol ; Yoo, Hye-Jin ; Kang, Hyun Joo ; Song, Wook ; Park, Seok Won ; Baik, Sei-Hyun ; Newman, Anne B. ; Choi, Kyung Mook. / Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study : The Korean Sarcopenic Obesity Study (KSOS). In: PLoS One. 2014 ; Vol. 9, No. 12.
@article{9c2bd05845344b84905ad5b75322e6ec,
title = "Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study: The Korean Sarcopenic Obesity Study (KSOS)",
abstract = "Objectives: Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. Methods: We observed changes in anthropometric and body composition data during a follow-up period of 27.6±2.8 months in 379 Korean men and women (mean age 51.9±14.6 years) from the Korean Sarcopenic Obesity Study (KSOS). Appendicular lean soft tissue (ALST) mass was calculated using dual-energy X-ray absorptiometry, and visceral fat area (VFA) was measured using computed tomography at baseline and follow-up examination. Results: ALST mass significantly decreased, whereas trunk and total fat mass increased in both men and women despite no significant change in weight and body mass index. In particular, women with visceral obesity at baseline had a greater decrease in ALST mass than those without visceral obesity (P=0.001). In multiple linear regression analysis, baseline VFA was an independent negative predictor of the changes in ALST after adjusting for confounding factors including age, gender, life style and body composition parameters, insulin resistance, high sensitivity C-reactive protein and vitamin D levels (P=0.001), whereas the association between baseline ALST mass and changes in VFA was not statistically significant (P=0.555). Conclusions: This longitudinal study showed that visceral obesity was associated with future loss of skeletal muscle mass in Korean adults. These results may provide novel insight into sarcopenic obesity in an aging society.",
author = "Kim, {Tae Nyun} and Park, {Man Sik} and Ryu, {Ja Young} and Choi, {Hae Yoon} and Hong, {Ho Cheol} and Hye-Jin Yoo and Kang, {Hyun Joo} and Wook Song and Park, {Seok Won} and Sei-Hyun Baik and Newman, {Anne B.} and Choi, {Kyung Mook}",
year = "2014",
month = "12",
day = "17",
doi = "10.1371/journal.pone.0115407",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

TY - JOUR

T1 - Impact of visceral fat on skeletal muscle mass and vice versa in a prospective cohort study

T2 - The Korean Sarcopenic Obesity Study (KSOS)

AU - Kim, Tae Nyun

AU - Park, Man Sik

AU - Ryu, Ja Young

AU - Choi, Hae Yoon

AU - Hong, Ho Cheol

AU - Yoo, Hye-Jin

AU - Kang, Hyun Joo

AU - Song, Wook

AU - Park, Seok Won

AU - Baik, Sei-Hyun

AU - Newman, Anne B.

AU - Choi, Kyung Mook

PY - 2014/12/17

Y1 - 2014/12/17

N2 - Objectives: Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. Methods: We observed changes in anthropometric and body composition data during a follow-up period of 27.6±2.8 months in 379 Korean men and women (mean age 51.9±14.6 years) from the Korean Sarcopenic Obesity Study (KSOS). Appendicular lean soft tissue (ALST) mass was calculated using dual-energy X-ray absorptiometry, and visceral fat area (VFA) was measured using computed tomography at baseline and follow-up examination. Results: ALST mass significantly decreased, whereas trunk and total fat mass increased in both men and women despite no significant change in weight and body mass index. In particular, women with visceral obesity at baseline had a greater decrease in ALST mass than those without visceral obesity (P=0.001). In multiple linear regression analysis, baseline VFA was an independent negative predictor of the changes in ALST after adjusting for confounding factors including age, gender, life style and body composition parameters, insulin resistance, high sensitivity C-reactive protein and vitamin D levels (P=0.001), whereas the association between baseline ALST mass and changes in VFA was not statistically significant (P=0.555). Conclusions: This longitudinal study showed that visceral obesity was associated with future loss of skeletal muscle mass in Korean adults. These results may provide novel insight into sarcopenic obesity in an aging society.

AB - Objectives: Sarcopenia and visceral obesity have been suggested to aggravate each other, resulting in a vicious cycle. However, evidence based on prospective study is very limited. Our purpose was to investigate whether visceral fat promotes a decrease in skeletal muscle mass and vice versa. Methods: We observed changes in anthropometric and body composition data during a follow-up period of 27.6±2.8 months in 379 Korean men and women (mean age 51.9±14.6 years) from the Korean Sarcopenic Obesity Study (KSOS). Appendicular lean soft tissue (ALST) mass was calculated using dual-energy X-ray absorptiometry, and visceral fat area (VFA) was measured using computed tomography at baseline and follow-up examination. Results: ALST mass significantly decreased, whereas trunk and total fat mass increased in both men and women despite no significant change in weight and body mass index. In particular, women with visceral obesity at baseline had a greater decrease in ALST mass than those without visceral obesity (P=0.001). In multiple linear regression analysis, baseline VFA was an independent negative predictor of the changes in ALST after adjusting for confounding factors including age, gender, life style and body composition parameters, insulin resistance, high sensitivity C-reactive protein and vitamin D levels (P=0.001), whereas the association between baseline ALST mass and changes in VFA was not statistically significant (P=0.555). Conclusions: This longitudinal study showed that visceral obesity was associated with future loss of skeletal muscle mass in Korean adults. These results may provide novel insight into sarcopenic obesity in an aging society.

UR - http://www.scopus.com/inward/record.url?scp=84919341210&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84919341210&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0115407

DO - 10.1371/journal.pone.0115407

M3 - Article

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 12

M1 - e115407

ER -