Seismic codes generally require the consideration of the effect of cracks in the modeling of the structure and the use of dynamic analyses such as response spectrum analyses for high-rise RC building structures. Satisfying these requirements is not straightforward for high-rise RC coupled wall structures because a response spectrum analysis cannot account for the change of stiffness due to cracks in members in tension or compression. The objective of this study is to quantify the effect of the variation of reduced section properties due to cracking and the adopted analysis procedures such as equivalent lateral force and response spectrum analysis procedures on the estimation of member forces and drifts. A sixty-story RC building structure was taken as an example. Based on the observations of the analytical results, the followings are concluded: 1) The maximum values of story drift, axial force in shear wall, and shear force in coupling beam predicted by equivalent lateral force procedures are about twice as a large as those obtained by response spectrum analysis with the same amount of base shear. 2) The impacts of effective stiffness in coupling beams are the greatest in the interstory drift ratio and the base flexural moment in the wall while the difference in the other member forces is relatively small. 3) The effective stiffness in walls in response spectrum analysis has a significant influence on the lateral drift ratios, but a minimal effect on the member forces.