Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice

Seungrie Han, Soontaek Hong, Jiwon Mo, Dongmin Lee, Eunju Choi, June Seek Choi, Woong Sun, Hyun Woo Lee, Hyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalMolecules and Cells
Volume37
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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