Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice

Seungrie Han, Soontaek Hong, Jiwon Mo, Dongmin Lee, Eunju Choi, June Seek Choi, Woong Sun, Hyun Woo Lee, Hyun Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Inductive expression of early growth response 1 (Egr-1) in neurons is associated with many forms of neuronal activity. However, only a few Egr-1 target genes are known in the brain. The results of this study demonstrate that Egr-1 knockout (KO) mice display impaired contextual extinction learning and normal fear acquisition relative to wild-type (WT) control animals. Genome-wide microarray experiments revealed 368 differentially expressed genes in the hippocampus of Egr-1 WT exposed to different phases of a fear conditioning paradigm compared to gene expression profiles in the hippocampus of KO mice. Some of genes, such as serotonin receptor 2C (Htr2c), neuropeptide B (Npb), neuronal PAS domain protein 4 (Npas4), NPY receptor Y1 (Npy1r), fatty acid binding protein 7 (Fabp7), and neuropeptide Y (Npy) are known to regulate processing of fearful memories, and promoter analyses demonstrated that several of these genes contained Egr-1 binding sites. This study provides a useful list of potential Egr-1 target genes which may be regulated during fear memory processing.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalMolecules and Cells
Volume37
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Knockout Mice
Fear
Growth
Genes
Hippocampus
Receptor, Serotonin, 5-HT2C
Wild Animals
Neuropeptide Y
Transcriptome
Psychological Extinction
Binding Sites
Learning
Genome
Neurons
Brain

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice. / Han, Seungrie; Hong, Soontaek; Mo, Jiwon; Lee, Dongmin; Choi, Eunju; Choi, June Seek; Sun, Woong; Lee, Hyun Woo; Kim, Hyun.

In: Molecules and Cells, Vol. 37, No. 1, 01.01.2014, p. 24-30.

Research output: Contribution to journalArticle

Han, Seungrie ; Hong, Soontaek ; Mo, Jiwon ; Lee, Dongmin ; Choi, Eunju ; Choi, June Seek ; Sun, Woong ; Lee, Hyun Woo ; Kim, Hyun. / Impaired extinction of learned contextual fear memory in early growth response 1 knockout mice. In: Molecules and Cells. 2014 ; Vol. 37, No. 1. pp. 24-30.
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