Impaired transport function of the left atrium in patients with lone paroxysmal atrial fibrillation

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Abstract

Background: Although lone paroxysmal atrial fibrillation (LPAF) is clinically defined as an arrhythmia that occurs in the absence of structural heart disease, it has been suggested that the presence of anatomical substrate is related to LPAF. The aim of the present study is to determine whether structural and functional remodeling of the left atrium (LA) occurs in patients with LPAF, and to identify whether frequent episodes of atrial fibrillation (AF) contribute to LA remodeling. Methods and Results: Forty-five patients who diagnosed as LPAF and age-, gender-, and body mass index-matched healthy control subjects (n = 45) were enrolled. Patients were grouped based on the frequency of AF episodes. An echocardiography was performed >2 weeks after last episode of AF without antiarrhythmic drugs. There were no statistical differences in left ventricular (LV) diastolic and systolic functions as well as baseline characteristics between patients and controls, whereas, patients had significantly larger LA volume (LAV), lower active LA emptying fraction (LAEFactive, P = 0.009) and total LAEF (LAEFtotal, P = 0.005) compared with controls. Passive LAEF (LAEFpassive) was not different between patients and controls (P = 0.664). LAEFactive was significantly depressed in patients with frequent episodes of AF than the others (P = 0.034). Conclusions: Compared with healthy controls, patients with LPAF had increased LAV and depressed LAEFactive and LAEFtotal without accompanying compensatory increase in LAEFpassive. LAEF active was influenced by frequent episodes of AF. These findings may support the hypothesis that LPAF is "not-so-lone AF" and related to the concealed cardiac dysfunctions. (Echocardiography 2011;28:44-51)

Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalEchocardiography
Volume28
Issue number1
DOIs
Publication statusPublished - 2011 Jan 1

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Heart Atria
Atrial Fibrillation
Echocardiography
Atrial Remodeling
Anti-Arrhythmia Agents
Cardiac Arrhythmias
Heart Diseases
Healthy Volunteers
Body Mass Index

Keywords

  • atrial fibrillation
  • left atrium
  • remodeling

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

@article{4201574df8c44ba98b54cb72fae0bb35,
title = "Impaired transport function of the left atrium in patients with lone paroxysmal atrial fibrillation",
abstract = "Background: Although lone paroxysmal atrial fibrillation (LPAF) is clinically defined as an arrhythmia that occurs in the absence of structural heart disease, it has been suggested that the presence of anatomical substrate is related to LPAF. The aim of the present study is to determine whether structural and functional remodeling of the left atrium (LA) occurs in patients with LPAF, and to identify whether frequent episodes of atrial fibrillation (AF) contribute to LA remodeling. Methods and Results: Forty-five patients who diagnosed as LPAF and age-, gender-, and body mass index-matched healthy control subjects (n = 45) were enrolled. Patients were grouped based on the frequency of AF episodes. An echocardiography was performed >2 weeks after last episode of AF without antiarrhythmic drugs. There were no statistical differences in left ventricular (LV) diastolic and systolic functions as well as baseline characteristics between patients and controls, whereas, patients had significantly larger LA volume (LAV), lower active LA emptying fraction (LAEFactive, P = 0.009) and total LAEF (LAEFtotal, P = 0.005) compared with controls. Passive LAEF (LAEFpassive) was not different between patients and controls (P = 0.664). LAEFactive was significantly depressed in patients with frequent episodes of AF than the others (P = 0.034). Conclusions: Compared with healthy controls, patients with LPAF had increased LAV and depressed LAEFactive and LAEFtotal without accompanying compensatory increase in LAEFpassive. LAEF active was influenced by frequent episodes of AF. These findings may support the hypothesis that LPAF is {"}not-so-lone AF{"} and related to the concealed cardiac dysfunctions. (Echocardiography 2011;28:44-51)",
keywords = "atrial fibrillation, left atrium, remodeling",
author = "Shin, {Seung Yong} and Lim, {Hong Euy} and Choi, {Un Jung} and Choi, {Cheol Ung} and Kim, {Seong Hwan} and Kim, {Jin Won} and Kim, {Eung Ju} and Seung-Woon Rha and Park, {Chang Gyu} and Seo, {Hong Seog} and Oh, {Dong Joo} and Chol Shin and Kim, {Young Hoon}",
year = "2011",
month = "1",
day = "1",
doi = "10.1111/j.1540-8175.2010.01271.x",
language = "English",
volume = "28",
pages = "44--51",
journal = "Echocardiography",
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TY - JOUR

T1 - Impaired transport function of the left atrium in patients with lone paroxysmal atrial fibrillation

AU - Shin, Seung Yong

AU - Lim, Hong Euy

AU - Choi, Un Jung

AU - Choi, Cheol Ung

AU - Kim, Seong Hwan

AU - Kim, Jin Won

AU - Kim, Eung Ju

AU - Rha, Seung-Woon

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

AU - Shin, Chol

AU - Kim, Young Hoon

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Background: Although lone paroxysmal atrial fibrillation (LPAF) is clinically defined as an arrhythmia that occurs in the absence of structural heart disease, it has been suggested that the presence of anatomical substrate is related to LPAF. The aim of the present study is to determine whether structural and functional remodeling of the left atrium (LA) occurs in patients with LPAF, and to identify whether frequent episodes of atrial fibrillation (AF) contribute to LA remodeling. Methods and Results: Forty-five patients who diagnosed as LPAF and age-, gender-, and body mass index-matched healthy control subjects (n = 45) were enrolled. Patients were grouped based on the frequency of AF episodes. An echocardiography was performed >2 weeks after last episode of AF without antiarrhythmic drugs. There were no statistical differences in left ventricular (LV) diastolic and systolic functions as well as baseline characteristics between patients and controls, whereas, patients had significantly larger LA volume (LAV), lower active LA emptying fraction (LAEFactive, P = 0.009) and total LAEF (LAEFtotal, P = 0.005) compared with controls. Passive LAEF (LAEFpassive) was not different between patients and controls (P = 0.664). LAEFactive was significantly depressed in patients with frequent episodes of AF than the others (P = 0.034). Conclusions: Compared with healthy controls, patients with LPAF had increased LAV and depressed LAEFactive and LAEFtotal without accompanying compensatory increase in LAEFpassive. LAEF active was influenced by frequent episodes of AF. These findings may support the hypothesis that LPAF is "not-so-lone AF" and related to the concealed cardiac dysfunctions. (Echocardiography 2011;28:44-51)

AB - Background: Although lone paroxysmal atrial fibrillation (LPAF) is clinically defined as an arrhythmia that occurs in the absence of structural heart disease, it has been suggested that the presence of anatomical substrate is related to LPAF. The aim of the present study is to determine whether structural and functional remodeling of the left atrium (LA) occurs in patients with LPAF, and to identify whether frequent episodes of atrial fibrillation (AF) contribute to LA remodeling. Methods and Results: Forty-five patients who diagnosed as LPAF and age-, gender-, and body mass index-matched healthy control subjects (n = 45) were enrolled. Patients were grouped based on the frequency of AF episodes. An echocardiography was performed >2 weeks after last episode of AF without antiarrhythmic drugs. There were no statistical differences in left ventricular (LV) diastolic and systolic functions as well as baseline characteristics between patients and controls, whereas, patients had significantly larger LA volume (LAV), lower active LA emptying fraction (LAEFactive, P = 0.009) and total LAEF (LAEFtotal, P = 0.005) compared with controls. Passive LAEF (LAEFpassive) was not different between patients and controls (P = 0.664). LAEFactive was significantly depressed in patients with frequent episodes of AF than the others (P = 0.034). Conclusions: Compared with healthy controls, patients with LPAF had increased LAV and depressed LAEFactive and LAEFtotal without accompanying compensatory increase in LAEFpassive. LAEF active was influenced by frequent episodes of AF. These findings may support the hypothesis that LPAF is "not-so-lone AF" and related to the concealed cardiac dysfunctions. (Echocardiography 2011;28:44-51)

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KW - left atrium

KW - remodeling

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U2 - 10.1111/j.1540-8175.2010.01271.x

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