Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study

Kyung Mook Choi, Kyungdo Han, Sanghyun Park, Hye Soo Chung, Nam Hoon Kim, Hye-Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei-Hyun Baik, Yong Gyu Park, Seon Mee Kim

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7 Citations (Scopus)

Abstract

Although liver enzymes, such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), have recently been suggested as risk factors for cardiovascular diseases (CVD), impact on mortality after myocardial infarction (MI) or ischemic stroke (IS) was not previously examined. Using a population-based, nationwide cohort database, we explored the implication of GGT and aminotransferases on the development of CVD and all-cause mortality during a median 9.1 years of follow-up. Among 16,624,006 Korean adults, both GGT and aminotransferases exhibited a positive relationship with MI, IS, and mortality in a multivariate adjusted model. ALT and AST showed U-shaped associations with mortality, whereas GGT showed a positive linear relationship with mortality. The risk of 1-year mortality after MI or IS was significantly higher in the highest quartile of GGT compared to the lowest quartile (HR, 1.46; 95% CI, 1.40-1.52). The implication of GGT on MI, IS, and mortality persisted regardless of traditional cardiovascular risk parameters. This study demonstrated the unique pattern of association of ALT, AST, and GGT with the development of CVD and all-cause mortality in the Korean population. In particular, GGT showed the most robust linear relationship with mortality before and after cardiovascular events independent of risk factors.

Original languageEnglish
Article number3764
JournalScientific Reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Cohort Studies
Cardiovascular Diseases
Mortality
Liver
Enzymes
Population
Aspartate Aminotransferases
Alanine Transaminase
Stroke
Myocardial Infarction
Transaminases
Databases

ASJC Scopus subject areas

  • General

Cite this

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title = "Implication of liver enzymes on incident cardiovascular diseases and mortality: A nationwide population-based cohort study",
abstract = "Although liver enzymes, such as γ-glutamyltransferase (GGT), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), have recently been suggested as risk factors for cardiovascular diseases (CVD), impact on mortality after myocardial infarction (MI) or ischemic stroke (IS) was not previously examined. Using a population-based, nationwide cohort database, we explored the implication of GGT and aminotransferases on the development of CVD and all-cause mortality during a median 9.1 years of follow-up. Among 16,624,006 Korean adults, both GGT and aminotransferases exhibited a positive relationship with MI, IS, and mortality in a multivariate adjusted model. ALT and AST showed U-shaped associations with mortality, whereas GGT showed a positive linear relationship with mortality. The risk of 1-year mortality after MI or IS was significantly higher in the highest quartile of GGT compared to the lowest quartile (HR, 1.46; 95{\%} CI, 1.40-1.52). The implication of GGT on MI, IS, and mortality persisted regardless of traditional cardiovascular risk parameters. This study demonstrated the unique pattern of association of ALT, AST, and GGT with the development of CVD and all-cause mortality in the Korean population. In particular, GGT showed the most robust linear relationship with mortality before and after cardiovascular events independent of risk factors.",
author = "Choi, {Kyung Mook} and Kyungdo Han and Sanghyun Park and Chung, {Hye Soo} and Kim, {Nam Hoon} and Hye-Jin Yoo and Seo, {Ji A} and Kim, {Sin Gon} and Kim, {Nan Hee} and Sei-Hyun Baik and Park, {Yong Gyu} and Kim, {Seon Mee}",
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AU - Choi, Kyung Mook

AU - Han, Kyungdo

AU - Park, Sanghyun

AU - Chung, Hye Soo

AU - Kim, Nam Hoon

AU - Yoo, Hye-Jin

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Baik, Sei-Hyun

AU - Park, Yong Gyu

AU - Kim, Seon Mee

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