Implication of lymph node metastasis detected on 18F-FDG PET/CT for surgical planning in patients with peripheral intrahepatic cholangiocarcinoma

Tae Gyu Park, Young Dong Yu, Beom Jin Park, Gi Jeong Cheon, Sun Young Oh, Dong Sik Kim, Jae Gol Choe

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

OBJECTIVES: Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy after hepatocellular carcinoma. ICC can be divided into 2 types according to their location: peripheral and hilar types. Intense 18F-FDG uptake on PET was reported in peripheral ICC. However, the usefulness of PET/CT in detecting tumors and predicting prognosis in peripheral ICC has not been fully evaluated. In this study, we evaluated the clinical role of 18F-FDG PET/CT to predict the recurrence after the curative resection in patients with surgically indicated peripheral ICC. METHODS: Eighteen patients with ICC underwent preoperative CT and 18F-FDG PET/CT scans. SUVmax of tumor, tumor to normal liver SUV ratio (TNR), lymph node status evaluated by 18F-FDG PET/CT, tumor and lymph node size measured by CT, vascular invasion confirmed by pathology, and satellite nodules found on CT were compared between 1-year recurrence group and recurrence-free group by chi-square test. RESULTS: Of total 23 measurable lymph nodes, 4 nodes were positive and other 19 nodes were negative or equivocal on CT. Among those 23 nodes, 9 nodes were positive and other 14 nodes were negative on 18F-FDG PET/CT. The sensitivity and specificity of CT were 20.0% and 86.4%, and those of 18F-FDG PET/CT were 80.0% and 92.3%. In the comparison between 1-year recurrent and nonrecurrent groups, lymph node metastasis detected on F-FDG PET/CT had statistically positive correlation with the 1-year recurrence after surgical resection (P = 0.02). Other factors showed no statistically significant difference between the groups. CONCLUSION: We found that lymph node metastasis detected on 18F-FDG PET/CT correlated positively with 1-year recurrence after surgical resection in patients with peripheral ICC.

Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalClinical nuclear medicine
Volume39
Issue number1
DOIs
Publication statusPublished - 2014 Jan

Keywords

  • 1-year recurrence
  • F-FDG PET/CT
  • Lymph node metastasis
  • Peripheral intrahepatic cholangiocarcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Implication of lymph node metastasis detected on <sup>18</sup>F-FDG PET/CT for surgical planning in patients with peripheral intrahepatic cholangiocarcinoma'. Together they form a unique fingerprint.

  • Cite this