Implication of nonalcoholic fatty liver disease, metabolic syndrome, and subclinical inflammation on mild renal insufficiency

Ga Eun Nam, Soon Young Hwang, Hye Soo Chung, Ju Hee Choi, Hyun Jung Lee, Nam Hoon Kim, Hye-Jin Yoo, Ji A Seo, Sin Gon Kim, Nan Hee Kim, Sei-Hyun Baik, Kyung Mook Choi

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Abstract

Background. Limited information exists about the impact of nonalcoholic fatty liver disease (NAFLD) on mild renal insufficiency. We compared the relative influence of NAFLD, metabolic syndrome (MetS), and subclinical inflammation, alone or in combination, on mild renal insufficiency. Methods. This study included 1174 Korean adults. NAFLD was diagnosed using ultrasonography. Mild renal insufficiency was defined as an estimated glomerular filtration rate (eGFR) ≥ 60 and <90 mL/min/1.73m2. Results. In partial correlation analysis, several components of MetS and liver aminotransferase levels, but not highsensitivity C-reactive protein (hsCRP), were associated with eGFR. Multivariate logistic regression analysis demonstrated the independent association of NAFLD (P = 0 034) and MetS (P = 0 018) with mild renal insufficiency, but not elevated hsCRP (P = 0 885). Furthermore, NAFLD without the MetS group (odds ratio (95% confidence interval) = 1.56 (1.05-2.34)) or MetS without the NAFLD group (1.82 (1.11-3.00)) was associated with mild renal insufficiency after adjusting for confounding variables. However, individuals with high hsCRP showed no relationship with mild renal insufficiency, irrespective of the existence of NAFLD. Conclusions. This study demonstrated that NAFLD and MetS are independently associated with mild renal insufficiency, whereas subclinical inflammation did not affect the risk for mild renal insufficiency in Korean adults.

Original languageEnglish
Article number1835486
JournalInternational Journal of Endocrinology
Volume2018
DOIs
Publication statusPublished - 2018 Jan 1

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Renal Insufficiency
Inflammation
C-Reactive Protein
Glomerular Filtration Rate
Confounding Factors (Epidemiology)
Non-alcoholic Fatty Liver Disease
Transaminases
Ultrasonography
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Liver

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems

Cite this

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title = "Implication of nonalcoholic fatty liver disease, metabolic syndrome, and subclinical inflammation on mild renal insufficiency",
abstract = "Background. Limited information exists about the impact of nonalcoholic fatty liver disease (NAFLD) on mild renal insufficiency. We compared the relative influence of NAFLD, metabolic syndrome (MetS), and subclinical inflammation, alone or in combination, on mild renal insufficiency. Methods. This study included 1174 Korean adults. NAFLD was diagnosed using ultrasonography. Mild renal insufficiency was defined as an estimated glomerular filtration rate (eGFR) ≥ 60 and <90 mL/min/1.73m2. Results. In partial correlation analysis, several components of MetS and liver aminotransferase levels, but not highsensitivity C-reactive protein (hsCRP), were associated with eGFR. Multivariate logistic regression analysis demonstrated the independent association of NAFLD (P = 0 034) and MetS (P = 0 018) with mild renal insufficiency, but not elevated hsCRP (P = 0 885). Furthermore, NAFLD without the MetS group (odds ratio (95{\%} confidence interval) = 1.56 (1.05-2.34)) or MetS without the NAFLD group (1.82 (1.11-3.00)) was associated with mild renal insufficiency after adjusting for confounding variables. However, individuals with high hsCRP showed no relationship with mild renal insufficiency, irrespective of the existence of NAFLD. Conclusions. This study demonstrated that NAFLD and MetS are independently associated with mild renal insufficiency, whereas subclinical inflammation did not affect the risk for mild renal insufficiency in Korean adults.",
author = "Nam, {Ga Eun} and Hwang, {Soon Young} and Chung, {Hye Soo} and Choi, {Ju Hee} and Lee, {Hyun Jung} and Kim, {Nam Hoon} and Hye-Jin Yoo and Seo, {Ji A} and Kim, {Sin Gon} and Kim, {Nan Hee} and Sei-Hyun Baik and Choi, {Kyung Mook}",
year = "2018",
month = "1",
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T1 - Implication of nonalcoholic fatty liver disease, metabolic syndrome, and subclinical inflammation on mild renal insufficiency

AU - Nam, Ga Eun

AU - Hwang, Soon Young

AU - Chung, Hye Soo

AU - Choi, Ju Hee

AU - Lee, Hyun Jung

AU - Kim, Nam Hoon

AU - Yoo, Hye-Jin

AU - Seo, Ji A

AU - Kim, Sin Gon

AU - Kim, Nan Hee

AU - Baik, Sei-Hyun

AU - Choi, Kyung Mook

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background. Limited information exists about the impact of nonalcoholic fatty liver disease (NAFLD) on mild renal insufficiency. We compared the relative influence of NAFLD, metabolic syndrome (MetS), and subclinical inflammation, alone or in combination, on mild renal insufficiency. Methods. This study included 1174 Korean adults. NAFLD was diagnosed using ultrasonography. Mild renal insufficiency was defined as an estimated glomerular filtration rate (eGFR) ≥ 60 and <90 mL/min/1.73m2. Results. In partial correlation analysis, several components of MetS and liver aminotransferase levels, but not highsensitivity C-reactive protein (hsCRP), were associated with eGFR. Multivariate logistic regression analysis demonstrated the independent association of NAFLD (P = 0 034) and MetS (P = 0 018) with mild renal insufficiency, but not elevated hsCRP (P = 0 885). Furthermore, NAFLD without the MetS group (odds ratio (95% confidence interval) = 1.56 (1.05-2.34)) or MetS without the NAFLD group (1.82 (1.11-3.00)) was associated with mild renal insufficiency after adjusting for confounding variables. However, individuals with high hsCRP showed no relationship with mild renal insufficiency, irrespective of the existence of NAFLD. Conclusions. This study demonstrated that NAFLD and MetS are independently associated with mild renal insufficiency, whereas subclinical inflammation did not affect the risk for mild renal insufficiency in Korean adults.

AB - Background. Limited information exists about the impact of nonalcoholic fatty liver disease (NAFLD) on mild renal insufficiency. We compared the relative influence of NAFLD, metabolic syndrome (MetS), and subclinical inflammation, alone or in combination, on mild renal insufficiency. Methods. This study included 1174 Korean adults. NAFLD was diagnosed using ultrasonography. Mild renal insufficiency was defined as an estimated glomerular filtration rate (eGFR) ≥ 60 and <90 mL/min/1.73m2. Results. In partial correlation analysis, several components of MetS and liver aminotransferase levels, but not highsensitivity C-reactive protein (hsCRP), were associated with eGFR. Multivariate logistic regression analysis demonstrated the independent association of NAFLD (P = 0 034) and MetS (P = 0 018) with mild renal insufficiency, but not elevated hsCRP (P = 0 885). Furthermore, NAFLD without the MetS group (odds ratio (95% confidence interval) = 1.56 (1.05-2.34)) or MetS without the NAFLD group (1.82 (1.11-3.00)) was associated with mild renal insufficiency after adjusting for confounding variables. However, individuals with high hsCRP showed no relationship with mild renal insufficiency, irrespective of the existence of NAFLD. Conclusions. This study demonstrated that NAFLD and MetS are independently associated with mild renal insufficiency, whereas subclinical inflammation did not affect the risk for mild renal insufficiency in Korean adults.

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