Impregnation of vancomycin, gentamicin, and cefotaxime in a cement spacer for two-stage cementless reconstruction in infected total hip arthroplasty

Kyung Hoi Koo, Jin Won Yang, Se Hyun Cho, Hae Ryong Song, Hyung Bin Park, Yong Chan Ha, Jun Dong Chang, Shin Yoon Kim, Young Hoo Kim

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Twenty-two patients with infected total hip arthroplasty were treated with 2-stage arthroplasty, using a cement spacer impregnated with a combination of 3 thermostable antibiotics (vancomycin, gentamicin, and cefotaxime). Initially, implants were removed, and a spacer was inserted. Six to 12 weeks later, the spacer was removed, and the patients underwent reconstruction using cementless components. The patients were followed for an average of 41 months. One patient had a recurrence of infection and was treated with resection arthroplasty. The remaining 21 patients (95%) had no evidence of infection at the final follow-up. We recommend using the combination of these 3 antibiotics in the cement spacer for 2-stage reconstruction in infected hip arthroplasty when the causative organism is not identified in the culture of preoperative aspiration.

Original languageEnglish
Pages (from-to)882-892
Number of pages11
JournalJournal of Arthroplasty
Volume16
Issue number7
DOIs
Publication statusPublished - 2001

Keywords

  • Antibiotics
  • Arthroplasty
  • Cement spacer
  • Hip
  • Infection
  • Two-stage reconstruction

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

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