Improved endothelial function in patients with atrial fibrillation through maintenance of sinus rhythm by successful catheter ablation

Seung Yong Shin, Jin Oh Na, Hong Euy Lim, Cheol Ung Choi, Jongil Choi, Seong Hwan Kim, Eung Ju Kim, Sang Weon Park, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dong Joo Oh, Young Hoon Kim

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Abstract

Effect of Ablation on Endothelial Function. Background: Although atrial fibrillation (AF) is a risk factor for endothelial dysfunction (ED), the effect of catheter ablation (CA) on AF-associated ED has not been evaluated. The aims of this study are to determine if the degree of ED predicts the outcome of AF ablation and to evaluate whether ED can be improved through restoring sinus rhythm (SR) by successful CA. Methods: This study prospectively enrolled 80 subjects who underwent CA for AF (paroxysmal AF = 61, persistent AF = 19). Eighty subjects with no history of AF were enrolled as controls, all of whom were matched by age, gender, body mass index, and atherosclerotic risk factor distribution. Brachial artery flow-mediated dilatation (FMD) was measured at baseline, and at 1 month and 6 months post CA in AF subjects who remained in SR. Among controls, FMD was measured at baseline and at 6 months. We used high sensitivity C-reactive protein (hs-CRP), interleukin-6, soluble E- or P-selectin, and endothelin-1 as biomarker indices for inflammation and/or ED. Results: Compared with controls, AF subjects had lower FMD at baseline (FMD baseline, P < 0.001). After successful CA, FMD was significantly improved at 1 month and 6 months, nearly approaching control levels. A multivariate analysis revealed that FMD baseline, hs-CRP, and left atrial volume (LAV) were independent predictors for arrhythmia recurrence after CA. Other biomarkers were not related to rhythm outcome. Conclusion: AF subjects have significantly impaired FMD, which can be reversed through maintenance of SR by successful CA. FMD baseline, hs-CRP, and LAV are important predictors for AF recurrence after CA.

Original languageEnglish
Pages (from-to)376-382
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume22
Issue number4
DOIs
Publication statusPublished - 2011 Apr 1

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Catheter Ablation
Atrial Fibrillation
Maintenance
Dilatation
C-Reactive Protein
Biomarkers
Recurrence
P-Selectin
Brachial Artery
Endothelin-1
Cardiac Arrhythmias
Interleukin-6
Body Mass Index
Multivariate Analysis
Inflammation

Keywords

  • atrial fibrillation
  • C-reactive protein
  • catheter ablation
  • endothelial function
  • inflammation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

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title = "Improved endothelial function in patients with atrial fibrillation through maintenance of sinus rhythm by successful catheter ablation",
abstract = "Effect of Ablation on Endothelial Function. Background: Although atrial fibrillation (AF) is a risk factor for endothelial dysfunction (ED), the effect of catheter ablation (CA) on AF-associated ED has not been evaluated. The aims of this study are to determine if the degree of ED predicts the outcome of AF ablation and to evaluate whether ED can be improved through restoring sinus rhythm (SR) by successful CA. Methods: This study prospectively enrolled 80 subjects who underwent CA for AF (paroxysmal AF = 61, persistent AF = 19). Eighty subjects with no history of AF were enrolled as controls, all of whom were matched by age, gender, body mass index, and atherosclerotic risk factor distribution. Brachial artery flow-mediated dilatation (FMD) was measured at baseline, and at 1 month and 6 months post CA in AF subjects who remained in SR. Among controls, FMD was measured at baseline and at 6 months. We used high sensitivity C-reactive protein (hs-CRP), interleukin-6, soluble E- or P-selectin, and endothelin-1 as biomarker indices for inflammation and/or ED. Results: Compared with controls, AF subjects had lower FMD at baseline (FMD baseline, P < 0.001). After successful CA, FMD was significantly improved at 1 month and 6 months, nearly approaching control levels. A multivariate analysis revealed that FMD baseline, hs-CRP, and left atrial volume (LAV) were independent predictors for arrhythmia recurrence after CA. Other biomarkers were not related to rhythm outcome. Conclusion: AF subjects have significantly impaired FMD, which can be reversed through maintenance of SR by successful CA. FMD baseline, hs-CRP, and LAV are important predictors for AF recurrence after CA.",
keywords = "atrial fibrillation, C-reactive protein, catheter ablation, endothelial function, inflammation",
author = "Shin, {Seung Yong} and Na, {Jin Oh} and Lim, {Hong Euy} and Choi, {Cheol Ung} and Jongil Choi and Kim, {Seong Hwan} and Kim, {Eung Ju} and Park, {Sang Weon} and Seung-Woon Rha and Park, {Chang Gyu} and Seo, {Hong Seog} and Oh, {Dong Joo} and Kim, {Young Hoon}",
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doi = "10.1111/j.1540-8167.2010.01919.x",
language = "English",
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pages = "376--382",
journal = "Journal of Cardiovascular Electrophysiology",
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T1 - Improved endothelial function in patients with atrial fibrillation through maintenance of sinus rhythm by successful catheter ablation

AU - Shin, Seung Yong

AU - Na, Jin Oh

AU - Lim, Hong Euy

AU - Choi, Cheol Ung

AU - Choi, Jongil

AU - Kim, Seong Hwan

AU - Kim, Eung Ju

AU - Park, Sang Weon

AU - Rha, Seung-Woon

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Oh, Dong Joo

AU - Kim, Young Hoon

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Effect of Ablation on Endothelial Function. Background: Although atrial fibrillation (AF) is a risk factor for endothelial dysfunction (ED), the effect of catheter ablation (CA) on AF-associated ED has not been evaluated. The aims of this study are to determine if the degree of ED predicts the outcome of AF ablation and to evaluate whether ED can be improved through restoring sinus rhythm (SR) by successful CA. Methods: This study prospectively enrolled 80 subjects who underwent CA for AF (paroxysmal AF = 61, persistent AF = 19). Eighty subjects with no history of AF were enrolled as controls, all of whom were matched by age, gender, body mass index, and atherosclerotic risk factor distribution. Brachial artery flow-mediated dilatation (FMD) was measured at baseline, and at 1 month and 6 months post CA in AF subjects who remained in SR. Among controls, FMD was measured at baseline and at 6 months. We used high sensitivity C-reactive protein (hs-CRP), interleukin-6, soluble E- or P-selectin, and endothelin-1 as biomarker indices for inflammation and/or ED. Results: Compared with controls, AF subjects had lower FMD at baseline (FMD baseline, P < 0.001). After successful CA, FMD was significantly improved at 1 month and 6 months, nearly approaching control levels. A multivariate analysis revealed that FMD baseline, hs-CRP, and left atrial volume (LAV) were independent predictors for arrhythmia recurrence after CA. Other biomarkers were not related to rhythm outcome. Conclusion: AF subjects have significantly impaired FMD, which can be reversed through maintenance of SR by successful CA. FMD baseline, hs-CRP, and LAV are important predictors for AF recurrence after CA.

AB - Effect of Ablation on Endothelial Function. Background: Although atrial fibrillation (AF) is a risk factor for endothelial dysfunction (ED), the effect of catheter ablation (CA) on AF-associated ED has not been evaluated. The aims of this study are to determine if the degree of ED predicts the outcome of AF ablation and to evaluate whether ED can be improved through restoring sinus rhythm (SR) by successful CA. Methods: This study prospectively enrolled 80 subjects who underwent CA for AF (paroxysmal AF = 61, persistent AF = 19). Eighty subjects with no history of AF were enrolled as controls, all of whom were matched by age, gender, body mass index, and atherosclerotic risk factor distribution. Brachial artery flow-mediated dilatation (FMD) was measured at baseline, and at 1 month and 6 months post CA in AF subjects who remained in SR. Among controls, FMD was measured at baseline and at 6 months. We used high sensitivity C-reactive protein (hs-CRP), interleukin-6, soluble E- or P-selectin, and endothelin-1 as biomarker indices for inflammation and/or ED. Results: Compared with controls, AF subjects had lower FMD at baseline (FMD baseline, P < 0.001). After successful CA, FMD was significantly improved at 1 month and 6 months, nearly approaching control levels. A multivariate analysis revealed that FMD baseline, hs-CRP, and left atrial volume (LAV) were independent predictors for arrhythmia recurrence after CA. Other biomarkers were not related to rhythm outcome. Conclusion: AF subjects have significantly impaired FMD, which can be reversed through maintenance of SR by successful CA. FMD baseline, hs-CRP, and LAV are important predictors for AF recurrence after CA.

KW - atrial fibrillation

KW - C-reactive protein

KW - catheter ablation

KW - endothelial function

KW - inflammation

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