Improved patency of transjugular intrahepatic portosystemic shunt: The efficacy of cilostazol for the prevention of pseudointimal hyperplasia in swine TIPS models

Sang Woo Park, In Ho Cha, Chul Hwan Kim, Hae Jeong Jeon, Jeong Hee Park, Suk Joo Hong, In Sik Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To investigate the efficacy of oral administration of cilostazol to inhibit pseudointimal/intimal hyperplasia in swine TIPS models. Methods: Successful TIPS creation was carried out in 11 of 12 healthy young pigs (20-25 kg). In the treatment group (n = 6), both cilostazol and aspirin were administered daily, from the first day of TIPS creation. The control group (n = 5) was administered only aspirin. The animals were followed-up for 2 weeks and then killed. The specimen (including portal vein, hepatic parenchymal tract, hepatic vein, and inferior vena cava) and stents were carefully bisected in a longitudinal fashion. The control group was compared with the treatment group by means of a gross and histologic evaluation of the degree of pseudointimal/intimal hyperplasia in the shunt. Results: At the gross evaluation, the control group showed considerably more pseudointimal/intimal hyperplasia than the treatment group. Using microscopic evaluation, there was a statistically significant difference (p < 0.05) in the mean maximum pseudointimal/intimal hyperplasia thickness between the control group (2.97 ± 0.33 mm) and treatment group (0.73 ± 0.27 mm). Conclusion: Oral administration of cilostazol may have been effective in reducing pseudointimal/intimal hyperplasia in swine TIPS models.

Original languageEnglish
Pages (from-to)719-724
Number of pages6
JournalCardioVascular and Interventional Radiology
Volume30
Issue number4
DOIs
Publication statusPublished - 2007 Jul

Keywords

  • Experimental studies
  • Interventional procedures
  • Liver

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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