Improved patency of transjugular intrahepatic portosystemic shunt: The efficacy of cilostazol for the prevention of pseudointimal hyperplasia in swine TIPS models

Sang Woo Park, In Ho Cha, Chul Hwan Kim, Hae Jeong Jeon, Jeong Hee Park, Suk-Joo Hong, In Sik Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: To investigate the efficacy of oral administration of cilostazol to inhibit pseudointimal/intimal hyperplasia in swine TIPS models. Methods: Successful TIPS creation was carried out in 11 of 12 healthy young pigs (20-25 kg). In the treatment group (n = 6), both cilostazol and aspirin were administered daily, from the first day of TIPS creation. The control group (n = 5) was administered only aspirin. The animals were followed-up for 2 weeks and then killed. The specimen (including portal vein, hepatic parenchymal tract, hepatic vein, and inferior vena cava) and stents were carefully bisected in a longitudinal fashion. The control group was compared with the treatment group by means of a gross and histologic evaluation of the degree of pseudointimal/intimal hyperplasia in the shunt. Results: At the gross evaluation, the control group showed considerably more pseudointimal/intimal hyperplasia than the treatment group. Using microscopic evaluation, there was a statistically significant difference (p < 0.05) in the mean maximum pseudointimal/intimal hyperplasia thickness between the control group (2.97 ± 0.33 mm) and treatment group (0.73 ± 0.27 mm). Conclusion: Oral administration of cilostazol may have been effective in reducing pseudointimal/intimal hyperplasia in swine TIPS models.

Original languageEnglish
Pages (from-to)719-724
Number of pages6
JournalCardioVascular and Interventional Radiology
Volume30
Issue number4
DOIs
Publication statusPublished - 2007 Jul 1

Keywords

  • Experimental studies
  • Interventional procedures
  • Liver

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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