Abstract
A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.
| Original language | English |
|---|---|
| Pages (from-to) | 328-331 |
| Number of pages | 4 |
| Journal | Biochemical Engineering Journal |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 Dec 15 |
| Externally published | Yes |
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Keywords
- Ammonium
- Cation resin
- Epothilone
- Feeding time
- Sorangium cellulosum
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Chemical Engineering(all)
Cite this
Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture. / Park, Sang Woo; Han, Se Jong; Kim, Dong Shik; Sim, Sang Jun.
In: Biochemical Engineering Journal, Vol. 37, No. 3, 15.12.2007, p. 328-331.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture
AU - Park, Sang Woo
AU - Han, Se Jong
AU - Kim, Dong Shik
AU - Sim, Sang Jun
PY - 2007/12/15
Y1 - 2007/12/15
N2 - A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.
AB - A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.
KW - Ammonium
KW - Cation resin
KW - Epothilone
KW - Feeding time
KW - Sorangium cellulosum
UR - http://www.scopus.com/inward/record.url?scp=35548974646&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35548974646&partnerID=8YFLogxK
U2 - 10.1016/j.bej.2007.05.013
DO - 10.1016/j.bej.2007.05.013
M3 - Article
AN - SCOPUS:35548974646
VL - 37
SP - 328
EP - 331
JO - Biochemical Engineering Journal
JF - Biochemical Engineering Journal
SN - 1369-703X
IS - 3
ER -