Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture

Sang Woo Park, Se Jong Han, Dong Shik Kim, Sang Jun Sim

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalBiochemical Engineering Journal
Volume37
Issue number3
DOIs
Publication statusPublished - 2007 Dec 15
Externally publishedYes

Fingerprint

Epothilones
Cation Exchange Resins
Ammonium Compounds
Ion exchange
Resins
Positive ions
Antineoplastic Agents
Growth
epothilone B

Keywords

  • Ammonium
  • Cation resin
  • Epothilone
  • Feeding time
  • Sorangium cellulosum

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Chemical Engineering(all)

Cite this

Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture. / Park, Sang Woo; Han, Se Jong; Kim, Dong Shik; Sim, Sang Jun.

In: Biochemical Engineering Journal, Vol. 37, No. 3, 15.12.2007, p. 328-331.

Research output: Contribution to journalArticle

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