Abstract
A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.
| Original language | English |
|---|---|
| Pages (from-to) | 328-331 |
| Number of pages | 4 |
| Journal | Biochemical Engineering Journal |
| Volume | 37 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 Dec 15 |
Keywords
- Ammonium
- Cation resin
- Epothilone
- Feeding time
- Sorangium cellulosum
ASJC Scopus subject areas
- Biotechnology
- Environmental Engineering
- Bioengineering
- Biomedical Engineering
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Park, S. W., Han, S. J., Kim, D. S., & Sim, S. J. (2007). Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture. Biochemical Engineering Journal, 37(3), 328-331. https://doi.org/10.1016/j.bej.2007.05.013