Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture

Sang Woo Park; Se Jong Han; Dong Shik Kim; Sang Jun Sim

doi:10.1016/j.bej.2007.05.013

Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture

Sang Woo Park, Se Jong Han, Dong Shik Kim, Sang Jun Sim

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L^-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L^-1, which was 2.6 times greater than that of the control culture.

Original language	English
Pages (from-to)	328-331
Number of pages	4
Journal	Biochemical Engineering Journal
Volume	37
Issue number	3
DOIs	https://doi.org/10.1016/j.bej.2007.05.013
Publication status	Published - 2007 Dec 15
Externally published	Yes

Keywords

Ammonium
Cation resin
Epothilone
Feeding time
Sorangium cellulosum

ASJC Scopus subject areas

Biotechnology
Environmental Engineering
Bioengineering
Biomedical Engineering

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title = "Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture",

abstract = "A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.",

keywords = "Ammonium, Cation resin, Epothilone, Feeding time, Sorangium cellulosum",

author = "Park, {Sang Woo} and Han, {Se Jong} and Kim, {Dong Shik} and Sim, {Sang Jun}",

note = "Funding Information: This research was supported by New Chemical Process Program under contact number 10023883 and Huons Co., Ltd. Korea. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

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doi = "10.1016/j.bej.2007.05.013",

language = "English",

volume = "37",

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T1 - Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture

AU - Park, Sang Woo

AU - Han, Se Jong

AU - Kim, Dong Shik

AU - Sim, Sang Jun

N1 - Funding Information: This research was supported by New Chemical Process Program under contact number 10023883 and Huons Co., Ltd. Korea. Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007/12/15

Y1 - 2007/12/15

N2 - A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.

AB - A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.

KW - Ammonium

KW - Cation resin

KW - Epothilone

KW - Feeding time

KW - Sorangium cellulosum

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DO - 10.1016/j.bej.2007.05.013

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JO - Biochemical Engineering Journal

JF - Biochemical Engineering Journal

SN - 1369-703X

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Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture

Abstract

Keywords

ASJC Scopus subject areas

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