Improvement of epothilone B production by in situ removal of ammonium using cation exchange resin in Sorangium cellulosum culture

Sang Woo Park, Se Jong Han, Dong Shik Kim, Sang Jun Sim

Research output: Contribution to journalArticle

10 Citations (Scopus)


A cation exchange resin was added at different stages in the growth of Sorangium cellulosum cultures to remove excess ammonium, which has a negative influence on the production of the anticancer agent, epothilone. When 8 g L-1 of cation exchange resin were added at the mid-death phase, the ammonium removal reached 83% and the maximum production of epothilone was 14.3 mg L-1, which was 2.6 times greater than that of the control culture.

Original languageEnglish
Pages (from-to)328-331
Number of pages4
JournalBiochemical Engineering Journal
Issue number3
Publication statusPublished - 2007 Dec 15
Externally publishedYes



  • Ammonium
  • Cation resin
  • Epothilone
  • Feeding time
  • Sorangium cellulosum

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • Bioengineering
  • Biomedical Engineering

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