Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

Seulki Kim, Dong Hwa Cho, Dong Keon Kweon, Eun Hee Jang, Joo Yeon Hong, Seung Taik Lim

Research output: Contribution to journalArticle

Abstract

Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

Original languageEnglish
JournalFood Science and Biotechnology
DOIs
Publication statusAccepted/In press - 2020 Jan 1

Keywords

  • Carboxymethyl cellulose
  • Disintegration time
  • Low molecular hyaluronic acid
  • Mechanical properties
  • Orodispersible film

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology

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