Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

Seulki Kim; Dong Hwa Cho; Dong Keon Kweon; Eun Hee Jang; Joo Yeon Hong; Seung Taik Lim

doi:10.1007/s10068-020-00771-1

Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition

Seulki Kim, Dong Hwa Cho, Dong Keon Kweon, Eun Hee Jang, Joo Yeon Hong, Seung Taik Lim

Department of Biotechnology

Research output: Contribution to journal › Article

Abstract

Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

Original language	English
Journal	Food Science and Biotechnology
DOIs	https://doi.org/10.1007/s10068-020-00771-1
Publication status	Accepted/In press - 2020 Jan 1

Keywords

Carboxymethyl cellulose
Disintegration time
Low molecular hyaluronic acid
Mechanical properties
Orodispersible film

ASJC Scopus subject areas

Biotechnology
Food Science
Applied Microbiology and Biotechnology

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Kim, S., Cho, D. H., Kweon, D. K., Jang, E. H., Hong, J. Y., & Lim, S. T. (Accepted/In press). Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition. Food Science and Biotechnology. https://doi.org/10.1007/s10068-020-00771-1

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title = "Improvement of mechanical properties of orodispersible hyaluronic acid film by carboxymethyl cellulose addition",

abstract = "Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.",

keywords = "Carboxymethyl cellulose, Disintegration time, Low molecular hyaluronic acid, Mechanical properties, Orodispersible film",

author = "Seulki Kim and Cho, {Dong Hwa} and Kweon, {Dong Keon} and Jang, {Eun Hee} and Hong, {Joo Yeon} and Lim, {Seung Taik}",

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AU - Kim, Seulki

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AU - Kweon, Dong Keon

AU - Jang, Eun Hee

AU - Hong, Joo Yeon

AU - Lim, Seung Taik

PY - 2020/1/1

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N2 - Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

AB - Orodispersible films (ODF) were prepared with mixtures of hyaluronic acid (HA) and carboxymethyl cellulose (CMC), and the effect of CMC addition on the disintegration and mechanical properties of the composite films were examined. Low molecular weight HA (10 kDa) appeared more acceptable for ODF than high molecular weight HA (800 kDa) because of its rapid disintegration in the oral cavity. The composite films appeared similar to pullulan film with excellent transparency and surface smoothness. The disintegration time as well as mechanical properties of the films such as tensile strength and elongation at break were increased by the addition of CMC. Overall, the CMC addition, up to 35%, improved the mechanical properties of low molecular weight HA film within a proper range of disintegration time for ODF.

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KW - Mechanical properties

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