Improvement of testosterone deficiency by fermented Momordica charantia extracts in aging male rats

Kyeong Soo Lee, Hyun Pyo Kim, Hyun Jin Park, Young Geol Yoon

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


This study evaluated the efficacy of Momordica charantia (MC; bitter melon) extracts against andropause symptoms. We fermented MC with Lactobacillus plantarum and verified the ability of the fermented MC extracts (FMEs) to control testosterone deficiency by using aging male rats as an animal model of andropause. FME administration considerably increased total and free testosterone levels, muscle mass, forced swimming time, and total and motile sperm counts in aging male rats. In contrast, sex hormone-binding globulin, retroperitoneal fat, serum cholesterol, and triglyceride levels were significantly reduced in the treated groups compared to the non-treated control aging male rats. Furthermore, we observed that FME enhanced the expression of testosterone biosynthesis-related genes but reduced the expression of testosterone degradation-related genes in a mouse Leydig cell line. These results suggest that FME has effective pharmacological activities that increase and restore free testosterone levels and that FME may be employed as a promising natural product for alleviating testosterone deficiency syndrome.

Original languageEnglish
Pages (from-to)443-454
Number of pages12
JournalFood Science and Biotechnology
Issue number3
Publication statusPublished - 2021 Mar


  • Andropause
  • Fermentation
  • Lactic acid bacteria
  • Male climacteric syndrome
  • Momordica charantia
  • Testosterone deficiency

ASJC Scopus subject areas

  • Biotechnology
  • Food Science
  • Applied Microbiology and Biotechnology


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