Improvement of the mass sensitivity in flexural plate wave biosensor based on PZT thin film

Yong Seon Lee, Dae Sung Yoon, Tae Song Kim

Research output: Contribution to journalConference article

9 Citations (Scopus)

Abstract

This paper presents the fabrication and characterization of microfabricated FPW device based on the piezoelectric PZT (Zr/Ti = 52/48) thin films for biological sensor applications. And we investigated the improvement of mass sensitivity in the FPW devices by etching the PZT on the delay-line. For biosensor application, when we bind bio-molecules directly on the delay-line to the device, the mass of the sensing plate is increased and a decrease in wave velocity, or resonant frequency, of the device is observed. The sensitivity of flexural plate wave device is nano gram level in milliliter by measuring resonant frequency shift. This is characterized by Au deposition method which has the mass loading effect similar to adsorption of protein. In the case of biotin-streptavidin binding, the device shows the good frequency response to streptavidin addition on the biotin coated Au of membrane. The FITC (Fluorescein Isothiocyanate) is labeled on streptavidin to check the binding between biotin and streptavidin. This is verified by using a fluorescent microscopy.

Original languageEnglish
Pages (from-to)391-400
Number of pages10
JournalIntegrated Ferroelectrics
Volume69
DOIs
Publication statusPublished - 2005 Dec 1
Externally publishedYes
Event16th International Symposium on Integrated Ferroelectrics, ISIF-16 - Gyeongju, Korea, Republic of
Duration: 2004 Apr 52004 Apr 8

Fingerprint

Streptavidin
bioinstrumentation
Biosensors
Biotin
Electric delay lines
Thin films
biotin
Natural frequencies
thin films
delay lines
Frequency response
resonant frequencies
Etching
Microscopic examination
Fluorescein
Proteins
Membranes
Adsorption
Fabrication
Molecules

Keywords

  • Biosensor
  • FPW
  • MEMS
  • Piezoelectric
  • PZT
  • Sensitivity

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Control and Systems Engineering
  • Ceramics and Composites
  • Condensed Matter Physics
  • Electrical and Electronic Engineering
  • Materials Chemistry

Cite this

Improvement of the mass sensitivity in flexural plate wave biosensor based on PZT thin film. / Lee, Yong Seon; Yoon, Dae Sung; Kim, Tae Song.

In: Integrated Ferroelectrics, Vol. 69, 01.12.2005, p. 391-400.

Research output: Contribution to journalConference article

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