In-hospital outcome according to the initial management and the "thrombolysis in myocardial infarction risk score" of acute non-ST segment elevation myocardial infarction

Hae Chang Jeong, Ho Jeong Myung, Keun Ahn Young, Chull Chae Sung, Jo Kim Young, Ho Hur Seung, Hoon Choi Dong, Han Yoon Jung, Keon Chae Jei, Il Kim Doo, Kwon Koo Bon, Yong Hwang Jin, Kyu O. Seok, Sik Kim Kee, Tae Jeong Kyung, Jin Kim Chong, Sung Chung Wook, Soo Jang Yang, Chull Chae Shung, Hyun Kim Jong & 28 others Whan Seong In, Jong Hong Taek, Young Rhew Jae, Ho Chae In, Ok Kim Byung, Yong Lee Myoung, Chan Cho Myeong, Hee Lee Nae, Tae Jeong Kyoung, Jea Tahk Seung, Ho Bae Jang, Seung-Woon Rha, Soo Park Keum, Rok Han Kyoo, Hoon Ahn Tae, Hyun Kim Moo, Bae Seung Ki, Young Yang Ju, Yun Rhim Chong, Cheol Gwon Hyeon, Wook Park Seong, Youp Koh Young, Jae Joo Seung, Joong Kim Soo, Kyu Jin Dong, Man Cho Jin, Gwan Cho Jeong, Jung Park Seung

Research output: Contribution to journalArticle

Abstract

Background and Objectives: The current guidelines recommend an early invasive strategy for patients suffering with non-ST segment elevation myocardial infarction (NSTEMI). However, there is still debate about the timing of revascularization in patients with NSTEMI. To analyze the clinical efficacy of the timing of revascularization, we compared the in-hospital clinical outcome of NSTEMI patients from the Korea Acute Myocardial Infarction Registry (KAMIR) between the early and selective invasive therapeutic groups. Subjects and Methods: Between Nov. 2005 and Apr. 2007, 2762 acute NSTEMI patients (mean age=64.6 ± 12.8 years, 1847 males) were enrolled in the KAMIR. The therapeutic strategy of NSTEMI was categorized into early invasive treatment (within 48 hours, Group I mean age: 63.1 ± 13.1 years, 1085 males) and selective invasive treatment (Group II mean age: 66.5 ± 12.1 years, 762 males). The initial clinical status and the in-hospital mortality and morbidity rate were compared between these two groups. The in-hospital outcomes were also compared between the two groups according to each level of the Thrombolysis In Myocardial Infarction (TIMI) risk score. Results: There were significant differences in the mortality and morbidity rate between the groups (6.5% vs. 10.3%, respectively, p<0.001). According to TIMI risk score, there were no significant differences of mortality and morbidity for the low to moderate risk patients (5.3% vs. 7.8%, respectively, p=0.123 for the risk score 0-2, 6.4% vs. 8.7%, p=0.139 for the risk score 3-4). Conclusion: Early invasive treatment improves the hospital outcome for the high-risk NSTEMI patients. The use of abciximab, a low ejection fraction, a high Killip class, a high TIMI risk score and old age are the predictive factors of in-hospital mortality and morbidity.

Original languageEnglish
Pages (from-to)550-558
Number of pages9
JournalKorean Circulation Journal
Volume37
Issue number11
Publication statusPublished - 2007 Nov 1

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Myocardial Infarction
Morbidity
Korea
Hospital Mortality
Registries
Mortality
Therapeutics
Age Factors
Non-ST Elevated Myocardial Infarction
Guidelines

Keywords

  • Angioplasty
  • Myocardial infarction
  • Prognosis
  • Thrombolytic therapy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Internal Medicine

Cite this

In-hospital outcome according to the initial management and the "thrombolysis in myocardial infarction risk score" of acute non-ST segment elevation myocardial infarction. / Jeong, Hae Chang; Myung, Ho Jeong; Young, Keun Ahn; Sung, Chull Chae; Young, Jo Kim; Seung, Ho Hur; Dong, Hoon Choi; Jung, Han Yoon; Jei, Keon Chae; Doo, Il Kim; Bon, Kwon Koo; Jin, Yong Hwang; Seok, Kyu O.; Kee, Sik Kim; Kyung, Tae Jeong; Chong, Jin Kim; Wook, Sung Chung; Yang, Soo Jang; Shung, Chull Chae; Jong, Hyun Kim; In, Whan Seong; Taek, Jong Hong; Jae, Young Rhew; In, Ho Chae; Byung, Ok Kim; Myoung, Yong Lee; Myeong, Chan Cho; Nae, Hee Lee; Kyoung, Tae Jeong; Seung, Jea Tahk; Jang, Ho Bae; Rha, Seung-Woon; Keum, Soo Park; Kyoo, Rok Han; Tae, Hoon Ahn; Moo, Hyun Kim; Ki, Bae Seung; Ju, Young Yang; Chong, Yun Rhim; Hyeon, Cheol Gwon; Seong, Wook Park; Young, Youp Koh; Seung, Jae Joo; Soo, Joong Kim; Dong, Kyu Jin; Jin, Man Cho; Jeong, Gwan Cho; Seung, Jung Park.

In: Korean Circulation Journal, Vol. 37, No. 11, 01.11.2007, p. 550-558.

Research output: Contribution to journalArticle

Jeong, HC, Myung, HJ, Young, KA, Sung, CC, Young, JK, Seung, HH, Dong, HC, Jung, HY, Jei, KC, Doo, IK, Bon, KK, Jin, YH, Seok, KO, Kee, SK, Kyung, TJ, Chong, JK, Wook, SC, Yang, SJ, Shung, CC, Jong, HK, In, WS, Taek, JH, Jae, YR, In, HC, Byung, OK, Myoung, YL, Myeong, CC, Nae, HL, Kyoung, TJ, Seung, JT, Jang, HB, Rha, S-W, Keum, SP, Kyoo, RH, Tae, HA, Moo, HK, Ki, BS, Ju, YY, Chong, YR, Hyeon, CG, Seong, WP, Young, YK, Seung, JJ, Soo, JK, Dong, KJ, Jin, MC, Jeong, GC & Seung, JP 2007, 'In-hospital outcome according to the initial management and the "thrombolysis in myocardial infarction risk score" of acute non-ST segment elevation myocardial infarction', Korean Circulation Journal, vol. 37, no. 11, pp. 550-558.
Jeong, Hae Chang ; Myung, Ho Jeong ; Young, Keun Ahn ; Sung, Chull Chae ; Young, Jo Kim ; Seung, Ho Hur ; Dong, Hoon Choi ; Jung, Han Yoon ; Jei, Keon Chae ; Doo, Il Kim ; Bon, Kwon Koo ; Jin, Yong Hwang ; Seok, Kyu O. ; Kee, Sik Kim ; Kyung, Tae Jeong ; Chong, Jin Kim ; Wook, Sung Chung ; Yang, Soo Jang ; Shung, Chull Chae ; Jong, Hyun Kim ; In, Whan Seong ; Taek, Jong Hong ; Jae, Young Rhew ; In, Ho Chae ; Byung, Ok Kim ; Myoung, Yong Lee ; Myeong, Chan Cho ; Nae, Hee Lee ; Kyoung, Tae Jeong ; Seung, Jea Tahk ; Jang, Ho Bae ; Rha, Seung-Woon ; Keum, Soo Park ; Kyoo, Rok Han ; Tae, Hoon Ahn ; Moo, Hyun Kim ; Ki, Bae Seung ; Ju, Young Yang ; Chong, Yun Rhim ; Hyeon, Cheol Gwon ; Seong, Wook Park ; Young, Youp Koh ; Seung, Jae Joo ; Soo, Joong Kim ; Dong, Kyu Jin ; Jin, Man Cho ; Jeong, Gwan Cho ; Seung, Jung Park. / In-hospital outcome according to the initial management and the "thrombolysis in myocardial infarction risk score" of acute non-ST segment elevation myocardial infarction. In: Korean Circulation Journal. 2007 ; Vol. 37, No. 11. pp. 550-558.
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abstract = "Background and Objectives: The current guidelines recommend an early invasive strategy for patients suffering with non-ST segment elevation myocardial infarction (NSTEMI). However, there is still debate about the timing of revascularization in patients with NSTEMI. To analyze the clinical efficacy of the timing of revascularization, we compared the in-hospital clinical outcome of NSTEMI patients from the Korea Acute Myocardial Infarction Registry (KAMIR) between the early and selective invasive therapeutic groups. Subjects and Methods: Between Nov. 2005 and Apr. 2007, 2762 acute NSTEMI patients (mean age=64.6 ± 12.8 years, 1847 males) were enrolled in the KAMIR. The therapeutic strategy of NSTEMI was categorized into early invasive treatment (within 48 hours, Group I mean age: 63.1 ± 13.1 years, 1085 males) and selective invasive treatment (Group II mean age: 66.5 ± 12.1 years, 762 males). The initial clinical status and the in-hospital mortality and morbidity rate were compared between these two groups. The in-hospital outcomes were also compared between the two groups according to each level of the Thrombolysis In Myocardial Infarction (TIMI) risk score. Results: There were significant differences in the mortality and morbidity rate between the groups (6.5{\%} vs. 10.3{\%}, respectively, p<0.001). According to TIMI risk score, there were no significant differences of mortality and morbidity for the low to moderate risk patients (5.3{\%} vs. 7.8{\%}, respectively, p=0.123 for the risk score 0-2, 6.4{\%} vs. 8.7{\%}, p=0.139 for the risk score 3-4). Conclusion: Early invasive treatment improves the hospital outcome for the high-risk NSTEMI patients. The use of abciximab, a low ejection fraction, a high Killip class, a high TIMI risk score and old age are the predictive factors of in-hospital mortality and morbidity.",
keywords = "Angioplasty, Myocardial infarction, Prognosis, Thrombolytic therapy",
author = "Jeong, {Hae Chang} and Myung, {Ho Jeong} and Young, {Keun Ahn} and Sung, {Chull Chae} and Young, {Jo Kim} and Seung, {Ho Hur} and Dong, {Hoon Choi} and Jung, {Han Yoon} and Jei, {Keon Chae} and Doo, {Il Kim} and Bon, {Kwon Koo} and Jin, {Yong Hwang} and Seok, {Kyu O.} and Kee, {Sik Kim} and Kyung, {Tae Jeong} and Chong, {Jin Kim} and Wook, {Sung Chung} and Yang, {Soo Jang} and Shung, {Chull Chae} and Jong, {Hyun Kim} and In, {Whan Seong} and Taek, {Jong Hong} and Jae, {Young Rhew} and In, {Ho Chae} and Byung, {Ok Kim} and Myoung, {Yong Lee} and Myeong, {Chan Cho} and Nae, {Hee Lee} and Kyoung, {Tae Jeong} and Seung, {Jea Tahk} and Jang, {Ho Bae} and Seung-Woon Rha and Keum, {Soo Park} and Kyoo, {Rok Han} and Tae, {Hoon Ahn} and Moo, {Hyun Kim} and Ki, {Bae Seung} and Ju, {Young Yang} and Chong, {Yun Rhim} and Hyeon, {Cheol Gwon} and Seong, {Wook Park} and Young, {Youp Koh} and Seung, {Jae Joo} and Soo, {Joong Kim} and Dong, {Kyu Jin} and Jin, {Man Cho} and Jeong, {Gwan Cho} and Seung, {Jung Park}",
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TY - JOUR

T1 - In-hospital outcome according to the initial management and the "thrombolysis in myocardial infarction risk score" of acute non-ST segment elevation myocardial infarction

AU - Jeong, Hae Chang

AU - Myung, Ho Jeong

AU - Young, Keun Ahn

AU - Sung, Chull Chae

AU - Young, Jo Kim

AU - Seung, Ho Hur

AU - Dong, Hoon Choi

AU - Jung, Han Yoon

AU - Jei, Keon Chae

AU - Doo, Il Kim

AU - Bon, Kwon Koo

AU - Jin, Yong Hwang

AU - Seok, Kyu O.

AU - Kee, Sik Kim

AU - Kyung, Tae Jeong

AU - Chong, Jin Kim

AU - Wook, Sung Chung

AU - Yang, Soo Jang

AU - Shung, Chull Chae

AU - Jong, Hyun Kim

AU - In, Whan Seong

AU - Taek, Jong Hong

AU - Jae, Young Rhew

AU - In, Ho Chae

AU - Byung, Ok Kim

AU - Myoung, Yong Lee

AU - Myeong, Chan Cho

AU - Nae, Hee Lee

AU - Kyoung, Tae Jeong

AU - Seung, Jea Tahk

AU - Jang, Ho Bae

AU - Rha, Seung-Woon

AU - Keum, Soo Park

AU - Kyoo, Rok Han

AU - Tae, Hoon Ahn

AU - Moo, Hyun Kim

AU - Ki, Bae Seung

AU - Ju, Young Yang

AU - Chong, Yun Rhim

AU - Hyeon, Cheol Gwon

AU - Seong, Wook Park

AU - Young, Youp Koh

AU - Seung, Jae Joo

AU - Soo, Joong Kim

AU - Dong, Kyu Jin

AU - Jin, Man Cho

AU - Jeong, Gwan Cho

AU - Seung, Jung Park

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Background and Objectives: The current guidelines recommend an early invasive strategy for patients suffering with non-ST segment elevation myocardial infarction (NSTEMI). However, there is still debate about the timing of revascularization in patients with NSTEMI. To analyze the clinical efficacy of the timing of revascularization, we compared the in-hospital clinical outcome of NSTEMI patients from the Korea Acute Myocardial Infarction Registry (KAMIR) between the early and selective invasive therapeutic groups. Subjects and Methods: Between Nov. 2005 and Apr. 2007, 2762 acute NSTEMI patients (mean age=64.6 ± 12.8 years, 1847 males) were enrolled in the KAMIR. The therapeutic strategy of NSTEMI was categorized into early invasive treatment (within 48 hours, Group I mean age: 63.1 ± 13.1 years, 1085 males) and selective invasive treatment (Group II mean age: 66.5 ± 12.1 years, 762 males). The initial clinical status and the in-hospital mortality and morbidity rate were compared between these two groups. The in-hospital outcomes were also compared between the two groups according to each level of the Thrombolysis In Myocardial Infarction (TIMI) risk score. Results: There were significant differences in the mortality and morbidity rate between the groups (6.5% vs. 10.3%, respectively, p<0.001). According to TIMI risk score, there were no significant differences of mortality and morbidity for the low to moderate risk patients (5.3% vs. 7.8%, respectively, p=0.123 for the risk score 0-2, 6.4% vs. 8.7%, p=0.139 for the risk score 3-4). Conclusion: Early invasive treatment improves the hospital outcome for the high-risk NSTEMI patients. The use of abciximab, a low ejection fraction, a high Killip class, a high TIMI risk score and old age are the predictive factors of in-hospital mortality and morbidity.

AB - Background and Objectives: The current guidelines recommend an early invasive strategy for patients suffering with non-ST segment elevation myocardial infarction (NSTEMI). However, there is still debate about the timing of revascularization in patients with NSTEMI. To analyze the clinical efficacy of the timing of revascularization, we compared the in-hospital clinical outcome of NSTEMI patients from the Korea Acute Myocardial Infarction Registry (KAMIR) between the early and selective invasive therapeutic groups. Subjects and Methods: Between Nov. 2005 and Apr. 2007, 2762 acute NSTEMI patients (mean age=64.6 ± 12.8 years, 1847 males) were enrolled in the KAMIR. The therapeutic strategy of NSTEMI was categorized into early invasive treatment (within 48 hours, Group I mean age: 63.1 ± 13.1 years, 1085 males) and selective invasive treatment (Group II mean age: 66.5 ± 12.1 years, 762 males). The initial clinical status and the in-hospital mortality and morbidity rate were compared between these two groups. The in-hospital outcomes were also compared between the two groups according to each level of the Thrombolysis In Myocardial Infarction (TIMI) risk score. Results: There were significant differences in the mortality and morbidity rate between the groups (6.5% vs. 10.3%, respectively, p<0.001). According to TIMI risk score, there were no significant differences of mortality and morbidity for the low to moderate risk patients (5.3% vs. 7.8%, respectively, p=0.123 for the risk score 0-2, 6.4% vs. 8.7%, p=0.139 for the risk score 3-4). Conclusion: Early invasive treatment improves the hospital outcome for the high-risk NSTEMI patients. The use of abciximab, a low ejection fraction, a high Killip class, a high TIMI risk score and old age are the predictive factors of in-hospital mortality and morbidity.

KW - Angioplasty

KW - Myocardial infarction

KW - Prognosis

KW - Thrombolytic therapy

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