In-plane single-crystal-silicon microneedles for minimally invasive microfluid systems

Seung Joon Paik, Sangwon Byun, Jung Ming Lim, Yonghwa Park, Ahra Lee, Seok Chung, Junkeun Chang, Kukjin Chun, Dongil Cho

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

This paper reports an in-plane single-crystal-silicon microneedle array, its mechanical safety, its integration with a polydimethylsiloxane (PDMS) microfluid chip, as well as in vitro and ex vivo test results. The fabricated microneedle arrays have buried microchannels, which are fabricated by using the processes of anisotropic dry etching, isotropic dry etching, and trench-refilling. The microchannel diameter is about 20μm. Several needle dimensions and shapes were investigated, and the microneedle shape was optimized using mechanical strength analysis. A 100μm wide, 100μm thick, and 2mm long microneedle shaft with the tip taper angle 30° and the isosceles triangle tip shape is strong enough to endure 0.248mNm of out-of-plane bending moment and 6.28N of in-plane buckling load. Then, the microneedle array is integrated with a PDMS microfluid chip. The microneedle integrated microfluid chip is tested in vitro, by injecting black ink into a methanol-filled petridish, and Rhodamine B dye into 1% agarose gel through microchannels of the integrated microneedle. The integrated microfluid chip is also tested ex vivo, by injecting Rhodamine B dye into a chicken breast flesh. In this ex vivo test, the penetration force was measured. For the optimized microneedle shaft, the penetration force was 80.9mN, and this force is less than 1.3% of the buckling force, which is 6.28N.

Original languageEnglish
Pages (from-to)276-284
Number of pages9
JournalSensors and Actuators, A: Physical
Volume114
Issue number2-3
DOIs
Publication statusPublished - 2004 Sep 1
Externally publishedYes

Fingerprint

rhodamine B
Silicon
Microchannels
Dry etching
microchannels
chips
Single crystals
Polydimethylsiloxane
Buckling
single crystals
silicon
Coloring Agents
Dyes
buckling
rhodamine
Anisotropic etching
penetration
dyes
etching
Bending moments

Keywords

  • Diagnosis systems
  • Microfluid chip
  • Microneedle
  • PDMS

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Mechanical Engineering
  • Instrumentation

Cite this

In-plane single-crystal-silicon microneedles for minimally invasive microfluid systems. / Paik, Seung Joon; Byun, Sangwon; Lim, Jung Ming; Park, Yonghwa; Lee, Ahra; Chung, Seok; Chang, Junkeun; Chun, Kukjin; Cho, Dongil.

In: Sensors and Actuators, A: Physical, Vol. 114, No. 2-3, 01.09.2004, p. 276-284.

Research output: Contribution to journalArticle

Paik, SJ, Byun, S, Lim, JM, Park, Y, Lee, A, Chung, S, Chang, J, Chun, K & Cho, D 2004, 'In-plane single-crystal-silicon microneedles for minimally invasive microfluid systems', Sensors and Actuators, A: Physical, vol. 114, no. 2-3, pp. 276-284. https://doi.org/10.1016/j.sna.2003.12.029
Paik, Seung Joon ; Byun, Sangwon ; Lim, Jung Ming ; Park, Yonghwa ; Lee, Ahra ; Chung, Seok ; Chang, Junkeun ; Chun, Kukjin ; Cho, Dongil. / In-plane single-crystal-silicon microneedles for minimally invasive microfluid systems. In: Sensors and Actuators, A: Physical. 2004 ; Vol. 114, No. 2-3. pp. 276-284.
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AB - This paper reports an in-plane single-crystal-silicon microneedle array, its mechanical safety, its integration with a polydimethylsiloxane (PDMS) microfluid chip, as well as in vitro and ex vivo test results. The fabricated microneedle arrays have buried microchannels, which are fabricated by using the processes of anisotropic dry etching, isotropic dry etching, and trench-refilling. The microchannel diameter is about 20μm. Several needle dimensions and shapes were investigated, and the microneedle shape was optimized using mechanical strength analysis. A 100μm wide, 100μm thick, and 2mm long microneedle shaft with the tip taper angle 30° and the isosceles triangle tip shape is strong enough to endure 0.248mNm of out-of-plane bending moment and 6.28N of in-plane buckling load. Then, the microneedle array is integrated with a PDMS microfluid chip. The microneedle integrated microfluid chip is tested in vitro, by injecting black ink into a methanol-filled petridish, and Rhodamine B dye into 1% agarose gel through microchannels of the integrated microneedle. The integrated microfluid chip is also tested ex vivo, by injecting Rhodamine B dye into a chicken breast flesh. In this ex vivo test, the penetration force was measured. For the optimized microneedle shaft, the penetration force was 80.9mN, and this force is less than 1.3% of the buckling force, which is 6.28N.

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