In situ impact assessment of wastewater effluents by integrating multi-level biomarker responses in the pale chub (Zacco platypus)

Woo Keun Kim, Jinho Jung

Research output: Contribution to journalArticle

9 Citations (Scopus)


The integration of biomarker responses ranging from the molecular to the individual level is of great interest for measuring the toxic effects of hazardous chemicals or effluent mixtures on aquatic organisms. This study evaluated the effects of wastewater treatment plant (WWTP) effluents on the freshwater pale chub Zacco platypus by using multi-level biomarker responses at molecular [mRNA expression of catalase (CAT), superoxide dismutase (SOD), glutathione S-transferase (GST), and metallothionein (MT)], biochemical (enzyme activities of CAT, SOD, GST, and concentration of MT), and physiological [condition factor (CF) and liver somatic index (LSI)] levels. The mRNA expression levels of GST and MT in Z. platypus from a site downstream of a WWTP significantly increased by 2.2- and 4.5-fold (p

Original languageEnglish
Pages (from-to)246-251
Number of pages6
JournalEcotoxicology and Environmental Safety
Publication statusPublished - 2016 Jun 1



  • Bioaccumulation
  • Effluent
  • Heavy metal
  • Integrated biomarker response
  • Wastewater

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Public Health, Environmental and Occupational Health
  • Pollution

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