Abstract
The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.
Original language | English |
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Article number | 223903 |
Journal | Applied Physics Letters |
Volume | 90 |
Issue number | 22 |
DOIs | |
Publication status | Published - 2007 |
Externally published | Yes |
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)