Abstract
The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.
| Original language | English |
|---|---|
| Article number | 223903 |
| Journal | Applied Physics Letters |
| Volume | 90 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 2007 Jun 11 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)
Cite this
In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid. / Kwon, Tae Yun; Eom, Kilho; Park, Jae Hong; Yoon, Dae Sung; Kim, Tae Song; Lee, Hong Lim.
In: Applied Physics Letters, Vol. 90, No. 22, 223903, 11.06.2007.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid
AU - Kwon, Tae Yun
AU - Eom, Kilho
AU - Park, Jae Hong
AU - Yoon, Dae Sung
AU - Kim, Tae Song
AU - Lee, Hong Lim
PY - 2007/6/11
Y1 - 2007/6/11
N2 - The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.
AB - The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.
UR - http://www.scopus.com/inward/record.url?scp=34249884202&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34249884202&partnerID=8YFLogxK
U2 - 10.1063/1.2741053
DO - 10.1063/1.2741053
M3 - Article
AN - SCOPUS:34249884202
VL - 90
JO - Applied Physics Letters
JF - Applied Physics Letters
SN - 0003-6951
IS - 22
M1 - 223903
ER -