In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid

Tae Yun Kwon; Kilho Eom; Jae Hong Park; Dae Sung Yoon; Tae Song Kim; Hong Lim Lee

doi:10.1063/1.2741053

In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid

Tae Yun Kwon, Kilho Eom, Jae Hong Park, Dae Sung Yoon, Tae Song Kim, Hong Lim Lee

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.

Original language	English
Article number	223903
Journal	Applied Physics Letters
Volume	90
Issue number	22
DOIs	https://doi.org/10.1063/1.2741053
Publication status	Published - 2007
Externally published	Yes

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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title = "In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid",

abstract = "The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.",

author = "Kwon, {Tae Yun} and Kilho Eom and Park, {Jae Hong} and Yoon, {Dae Sung} and Kim, {Tae Song} and Lee, {Hong Lim}",

note = "Funding Information: This work was supported by Intelligent Microsystem Center sponsored by the Korea Ministry of Science and Technology as a part of the 21st Century{\textquoteright}s Frontier R&D projects (Grant No. MS-01-133-01) and the National Core Research Center for Nanomedical Technology sponsored by KOSEF (Grant No. R15-2004-024-00000-0). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

year = "2007",

doi = "10.1063/1.2741053",

language = "English",

volume = "90",

journal = "Applied Physics Letters",

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AU - Kwon, Tae Yun

AU - Eom, Kilho

AU - Park, Jae Hong

AU - Yoon, Dae Sung

AU - Kim, Tae Song

AU - Lee, Hong Lim

N1 - Funding Information: This work was supported by Intelligent Microsystem Center sponsored by the Korea Ministry of Science and Technology as a part of the 21st Century’s Frontier R&D projects (Grant No. MS-01-133-01) and the National Core Research Center for Nanomedical Technology sponsored by KOSEF (Grant No. R15-2004-024-00000-0). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

PY - 2007

Y1 - 2007

N2 - The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.

AB - The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.

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In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid

Abstract

ASJC Scopus subject areas

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