In situ real-time monitoring of biomolecular interactions based on resonating microcantilevers immersed in a viscous fluid

Tae Yun Kwon, Kilho Eom, Jae Hong Park, Dae Sung Yoon, Tae Song Kim, Hong Lim Lee

Research output: Contribution to journalArticle

58 Citations (Scopus)


The authors report the precise (noise-free) in situ real-time monitoring of a specific protein antigen-antibody interaction by using a resonating microcantilever immersed in a viscous fluid. In this work, they utilized a resonating piezoelectric thick film microcantilever, which exhibits the high quality factor (e.g., Q=15) in a viscous liquid at a viscosity comparable to that of human blood serum. This implies a great potential of the resonating microcantilever to in situ biosensor applications. It is shown that the microcantilever enables them to monitor the C reactive protein antigen-antibody interactions in real time, providing an insight into the protein binding kinetics.

Original languageEnglish
Article number223903
JournalApplied Physics Letters
Issue number22
Publication statusPublished - 2007 Jun 11
Externally publishedYes


ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

Cite this