In Vino Veritas: A Tale of Two Sirt1s?

Seung Hoi Koo; Marc Montminy

doi:10.1016/j.cell.2006.11.034

In Vino Veritas: A Tale of Two Sirt1s?

Seung Hoi Koo, Marc Montminy

Research output: Contribution to journal › Short survey › peer-review

50 Citations (Scopus)

Abstract

Resveratrol increases life span in lower organisms by activating the NAD⁺-dependent histone deacetylase Sirt1. Studies by Lagouge et al. (2006) and Baur et al. (2006) now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1α.

Original language	English
Pages (from-to)	1091-1093
Number of pages	3
Journal	Cell
Volume	127
Issue number	6
DOIs	https://doi.org/10.1016/j.cell.2006.11.034
Publication status	Published - 2006 Dec 15
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "In Vino Veritas: A Tale of Two Sirt1s?",

abstract = "Resveratrol increases life span in lower organisms by activating the NAD+-dependent histone deacetylase Sirt1. Studies by Lagouge et al. (2006) and Baur et al. (2006) now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1α.",

author = "Koo, {Seung Hoi} and Marc Montminy",

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AU - Montminy, Marc

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AB - Resveratrol increases life span in lower organisms by activating the NAD+-dependent histone deacetylase Sirt1. Studies by Lagouge et al. (2006) and Baur et al. (2006) now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1α.

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JO - Cell

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In Vino Veritas: A Tale of Two Sirt1s?

Abstract

ASJC Scopus subject areas

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