Abstract
Resveratrol increases life span in lower organisms by activating the NAD+-dependent histone deacetylase Sirt1. Studies by Lagouge et al. (2006) and Baur et al. (2006) now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1α.
| Original language | English |
|---|---|
| Pages (from-to) | 1091-1093 |
| Number of pages | 3 |
| Journal | Cell |
| Volume | 127 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2006 Dec 15 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
Cite this
In Vino Veritas : A Tale of Two Sirt1s? / Koo, Seung-Hoi; Montminy, Marc.
In: Cell, Vol. 127, No. 6, 15.12.2006, p. 1091-1093.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In Vino Veritas
T2 - A Tale of Two Sirt1s?
AU - Koo, Seung-Hoi
AU - Montminy, Marc
PY - 2006/12/15
Y1 - 2006/12/15
N2 - Resveratrol increases life span in lower organisms by activating the NAD+-dependent histone deacetylase Sirt1. Studies by Lagouge et al. (2006) and Baur et al. (2006) now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1α.
AB - Resveratrol increases life span in lower organisms by activating the NAD+-dependent histone deacetylase Sirt1. Studies by Lagouge et al. (2006) and Baur et al. (2006) now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1α.
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U2 - 10.1016/j.cell.2006.11.034
DO - 10.1016/j.cell.2006.11.034
M3 - Article
VL - 127
SP - 1091
EP - 1093
JO - Cell
JF - Cell
SN - 0092-8674
IS - 6
ER -