In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii

Joon-Young Song, Sae Yoon Kee, In Sook Hwang, Yu Bin Seo, Hye Won Jeong, Woo Joo Kim, Hee-Jin Cheong

Research output: Contribution to journalArticle

88 Citations (Scopus)

Abstract

Objectives: To determine the in vitro activities and interactions of imipenem, colistin and tigecycline with old antibacterial agents against carbapenem-resistant Acinetobacter baumannii. Methods: Forty-three carbapenem-resistant A. baumannii isolates from the intensive care unit of a university hospital were collected and their MICs of imipenem, colistin and tigecycline were determined. With eight randomly selected carbapenem-resistant isolates, an in vitro time-kill study was performed for the evaluation of antibacterial activity of colistin, tigecycline, imipenem/sulbactam and colistin/rifampicin. Results: The time-kill study of colistin demonstrated bactericidal activity against A. baumannii at concentrations of 4 × MIC and 8 × MIC, whereas tigecycline showed bacteriostatic activity at all concentrations. The combination regimens of imipenem/sulbactam and colistin/rifampicin were synergistic and bactericidal at 1 × MIC. Conclusions: Imipenem/sulbactam combination, colistin and tigecycline showed good in vitro activities against carbapenem-resistant A. baumannii isolates. Even though colistin is bactericidal against carbapenem-resistant A. baumannii, the colistin/rifampicin combination is more warranted in order to be certain.

Original languageEnglish
Pages (from-to)317-322
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume60
Issue number2
DOIs
Publication statusPublished - 2007 Aug 1

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Colistin
Sulbactam
Acinetobacter baumannii
Carbapenems
Rifampin
Imipenem
tigecycline
In Vitro Techniques
Intensive Care Units
Anti-Bacterial Agents

Keywords

  • A. baumannii
  • Synergy
  • Time-kill assay

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

Cite this

@article{ca075763629e4702bae98d8a0040e951,
title = "In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii",
abstract = "Objectives: To determine the in vitro activities and interactions of imipenem, colistin and tigecycline with old antibacterial agents against carbapenem-resistant Acinetobacter baumannii. Methods: Forty-three carbapenem-resistant A. baumannii isolates from the intensive care unit of a university hospital were collected and their MICs of imipenem, colistin and tigecycline were determined. With eight randomly selected carbapenem-resistant isolates, an in vitro time-kill study was performed for the evaluation of antibacterial activity of colistin, tigecycline, imipenem/sulbactam and colistin/rifampicin. Results: The time-kill study of colistin demonstrated bactericidal activity against A. baumannii at concentrations of 4 × MIC and 8 × MIC, whereas tigecycline showed bacteriostatic activity at all concentrations. The combination regimens of imipenem/sulbactam and colistin/rifampicin were synergistic and bactericidal at 1 × MIC. Conclusions: Imipenem/sulbactam combination, colistin and tigecycline showed good in vitro activities against carbapenem-resistant A. baumannii isolates. Even though colistin is bactericidal against carbapenem-resistant A. baumannii, the colistin/rifampicin combination is more warranted in order to be certain.",
keywords = "A. baumannii, Synergy, Time-kill assay",
author = "Joon-Young Song and Kee, {Sae Yoon} and Hwang, {In Sook} and Seo, {Yu Bin} and Jeong, {Hye Won} and Kim, {Woo Joo} and Hee-Jin Cheong",
year = "2007",
month = "8",
day = "1",
doi = "10.1093/jac/dkm136",
language = "English",
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T1 - In vitro activities of carbapenem/sulbactam combination, colistin, colistin/rifampicin combination and tigecycline against carbapenem-resistant Acinetobacter baumannii

AU - Song, Joon-Young

AU - Kee, Sae Yoon

AU - Hwang, In Sook

AU - Seo, Yu Bin

AU - Jeong, Hye Won

AU - Kim, Woo Joo

AU - Cheong, Hee-Jin

PY - 2007/8/1

Y1 - 2007/8/1

N2 - Objectives: To determine the in vitro activities and interactions of imipenem, colistin and tigecycline with old antibacterial agents against carbapenem-resistant Acinetobacter baumannii. Methods: Forty-three carbapenem-resistant A. baumannii isolates from the intensive care unit of a university hospital were collected and their MICs of imipenem, colistin and tigecycline were determined. With eight randomly selected carbapenem-resistant isolates, an in vitro time-kill study was performed for the evaluation of antibacterial activity of colistin, tigecycline, imipenem/sulbactam and colistin/rifampicin. Results: The time-kill study of colistin demonstrated bactericidal activity against A. baumannii at concentrations of 4 × MIC and 8 × MIC, whereas tigecycline showed bacteriostatic activity at all concentrations. The combination regimens of imipenem/sulbactam and colistin/rifampicin were synergistic and bactericidal at 1 × MIC. Conclusions: Imipenem/sulbactam combination, colistin and tigecycline showed good in vitro activities against carbapenem-resistant A. baumannii isolates. Even though colistin is bactericidal against carbapenem-resistant A. baumannii, the colistin/rifampicin combination is more warranted in order to be certain.

AB - Objectives: To determine the in vitro activities and interactions of imipenem, colistin and tigecycline with old antibacterial agents against carbapenem-resistant Acinetobacter baumannii. Methods: Forty-three carbapenem-resistant A. baumannii isolates from the intensive care unit of a university hospital were collected and their MICs of imipenem, colistin and tigecycline were determined. With eight randomly selected carbapenem-resistant isolates, an in vitro time-kill study was performed for the evaluation of antibacterial activity of colistin, tigecycline, imipenem/sulbactam and colistin/rifampicin. Results: The time-kill study of colistin demonstrated bactericidal activity against A. baumannii at concentrations of 4 × MIC and 8 × MIC, whereas tigecycline showed bacteriostatic activity at all concentrations. The combination regimens of imipenem/sulbactam and colistin/rifampicin were synergistic and bactericidal at 1 × MIC. Conclusions: Imipenem/sulbactam combination, colistin and tigecycline showed good in vitro activities against carbapenem-resistant A. baumannii isolates. Even though colistin is bactericidal against carbapenem-resistant A. baumannii, the colistin/rifampicin combination is more warranted in order to be certain.

KW - A. baumannii

KW - Synergy

KW - Time-kill assay

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SN - 0305-7453

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