Abstract
The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checker-board test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were <32 μg/ml and <64 μg/ml for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.
Original language | English |
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Pages (from-to) | 473-477 |
Number of pages | 5 |
Journal | Journal of Microbiology |
Volume | 45 |
Issue number | 5 |
Publication status | Published - 2007 Oct |
Keywords
- Checkerboard test
- Clindamycin
- Erythromycin
- Kaempferol
- Propionibacterium acnes
ASJC Scopus subject areas
- Microbiology
- Applied Microbiology and Biotechnology