In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes

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Abstract

The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checker-board test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were <32 μg/ml and <64 μg/ml for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.

Original languageEnglish
Pages (from-to)473-477
Number of pages5
JournalJournal of Microbiology
Volume45
Issue number5
Publication statusPublished - 2007 Oct 1

Keywords

  • Checkerboard test
  • Clindamycin
  • Erythromycin
  • Kaempferol
  • Propionibacterium acnes

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

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