Abstract
The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checker-board test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were <32 μg/ml and <64 μg/ml for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.
| Original language | English |
|---|---|
| Pages (from-to) | 473-477 |
| Number of pages | 5 |
| Journal | Journal of Microbiology |
| Volume | 45 |
| Issue number | 5 |
| Publication status | Published - 2007 Oct 1 |
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Keywords
- Checkerboard test
- Clindamycin
- Erythromycin
- Kaempferol
- Propionibacterium acnes
ASJC Scopus subject areas
- Microbiology
- Applied Microbiology and Biotechnology
Cite this
In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes. / Lim, Young Hee; Kim, In-Hwan; Seo, Jung Ju.
In: Journal of Microbiology, Vol. 45, No. 5, 01.10.2007, p. 473-477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro activity of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin against Propionibacterium acnes
AU - Lim, Young Hee
AU - Kim, In-Hwan
AU - Seo, Jung Ju
PY - 2007/10/1
Y1 - 2007/10/1
N2 - The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checker-board test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were <32 μg/ml and <64 μg/ml for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.
AB - The in vitro antibacterial activity against antibiotic-resistant Propionibacterium acnes of kaempferol isolated from the Impatiens balsamina alone and in combination with erythromycin or clindamycin antibiotics was investigated. The antibiotic combination effect against antibiotic-resistant P. acnes was studied by checker-board test. Kaempferol and quercetin demonstrated antibacterial activities against P. acnes. Minimum inhibitory concentrations (MICs) for both compounds were <32 μg/ml and <64 μg/ml for clindamycin-sensitive and -resistant P. acnes, respectively. The four combination formulations (kaempferol and either erythromycin or clindamycin; quercetin and either erythromycin or clindamycin) exhibited a synergic inhibition of P. acnes growth. The combination of kaempferol with quercetin showed an indifferent effect. The combination of clindamycin with kaempferol or quercetin showed a greater synergic effect than that of erythromycin with kaempferol or quercetin. Thus, these combinations demonstrated the potential to treat acne.
KW - Checkerboard test
KW - Clindamycin
KW - Erythromycin
KW - Kaempferol
KW - Propionibacterium acnes
UR - http://www.scopus.com/inward/record.url?scp=35648995463&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35648995463&partnerID=8YFLogxK
M3 - Article
C2 - 17978809
AN - SCOPUS:35648995463
VL - 45
SP - 473
EP - 477
JO - Journal of Microbiology
JF - Journal of Microbiology
SN - 1225-8873
IS - 5
ER -