In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres

Sung Eun Kim, Young Pil Yun, Kyu Sik Shim, Daniel I. Jeon, Kyeongsoon Park, Hak Jun Kim

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.

    Original languageEnglish
    Pages (from-to)123-130
    Number of pages8
    JournalJournal of Industrial and Engineering Chemistry
    Volume58
    DOIs
    Publication statusPublished - 2018 Feb 25

    Keywords

    • Anti-inflammatory effect
    • Collagenase-induced Achilles tendinopathy
    • Curcumin
    • Porous microspheres
    • Tendon healing

    ASJC Scopus subject areas

    • Chemical Engineering(all)

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