Abstract
Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.
| Original language | English |
|---|---|
| Pages (from-to) | 123-130 |
| Number of pages | 8 |
| Journal | Journal of Industrial and Engineering Chemistry |
| Volume | 58 |
| DOIs | |
| Publication status | Published - 2018 Feb 25 |
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Keywords
- Anti-inflammatory effect
- Collagenase-induced Achilles tendinopathy
- Curcumin
- Porous microspheres
- Tendon healing
ASJC Scopus subject areas
- Chemical Engineering(all)
Cite this
In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres. / Kim, Sung Eun; Yun, Young Pil; Shim, Kyu Sik; Jeon, Daniel I.; Park, Kyeongsoon; Kim, Hak Jun.
In: Journal of Industrial and Engineering Chemistry, Vol. 58, 25.02.2018, p. 123-130.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres
AU - Kim, Sung Eun
AU - Yun, Young Pil
AU - Shim, Kyu Sik
AU - Jeon, Daniel I.
AU - Park, Kyeongsoon
AU - Kim, Hak Jun
PY - 2018/2/25
Y1 - 2018/2/25
N2 - Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.
AB - Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.
KW - Anti-inflammatory effect
KW - Collagenase-induced Achilles tendinopathy
KW - Curcumin
KW - Porous microspheres
KW - Tendon healing
UR - http://www.scopus.com/inward/record.url?scp=85032633131&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032633131&partnerID=8YFLogxK
U2 - 10.1016/j.jiec.2017.09.016
DO - 10.1016/j.jiec.2017.09.016
M3 - Article
AN - SCOPUS:85032633131
VL - 58
SP - 123
EP - 130
JO - Journal of Industrial and Engineering Chemistry
JF - Journal of Industrial and Engineering Chemistry
SN - 1226-086X
ER -