Abstract
Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.
Original language | English |
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Pages (from-to) | 123-130 |
Number of pages | 8 |
Journal | Journal of Industrial and Engineering Chemistry |
Volume | 58 |
DOIs | |
Publication status | Published - 2018 Feb 25 |
Keywords
- Anti-inflammatory effect
- Collagenase-induced Achilles tendinopathy
- Curcumin
- Porous microspheres
- Tendon healing
ASJC Scopus subject areas
- Chemical Engineering(all)