In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres

Sung Eun Kim; Young Pil Yun; Kyu Sik Shim; Daniel I. Jeon; Kyeongsoon Park; Hak Jun Kim

doi:10.1016/j.jiec.2017.09.016

In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres

Sung Eun Kim, Young Pil Yun, Kyu Sik Shim, Daniel I. Jeon, Kyeongsoon Park, Hak Jun Kim

Department of Orthopedic Surgery

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.

Original language	English
Pages (from-to)	123-130
Number of pages	8
Journal	Journal of Industrial and Engineering Chemistry
Volume	58
DOIs	https://doi.org/10.1016/j.jiec.2017.09.016
Publication status	Published - 2018 Feb 25

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Keywords

Anti-inflammatory effect
Collagenase-induced Achilles tendinopathy
Curcumin
Porous microspheres
Tendon healing

ASJC Scopus subject areas

Chemical Engineering(all)

Cite this

Kim, S. E., Yun, Y. P., Shim, K. S., Jeon, D. I., Park, K., & Kim, H. J. (2018). In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres. Journal of Industrial and Engineering Chemistry, 58, 123-130. https://doi.org/10.1016/j.jiec.2017.09.016

In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres. / Kim, Sung Eun; Yun, Young Pil; Shim, Kyu Sik; Jeon, Daniel I.; Park, Kyeongsoon; Kim, Hak Jun.

In: Journal of Industrial and Engineering Chemistry, Vol. 58, 25.02.2018, p. 123-130.

Research output: Contribution to journal › Article

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AB - Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.

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10.1016/j.jiec.2017.09.016