In vitro and in vivo anti-inflammatory and tendon-healing effects in Achilles tendinopathy of long-term curcumin delivery using porous microspheres

Sung Eun Kim, Young Pil Yun, Kyu Sik Shim, Daniel I. Jeon, Kyeongsoon Park, Hak Jun Kim

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Achilles tendinopathy is a debilitating musculoskeletal condition that causes significant pain and leads to tendon rupture. Cur/PMSs exerted anti-inflammatory effects on LPS-treated tenocytes in a dose-dependent manner by showing significant decreases in the expression of pro-inflammatory markers such as MMP-3 and MMP-13, COX-2, ADAMTS-5, IL-6, and TNF-α. We demonstrated that local injection of Cur/PMSs markedly suppressed the expression of pro-inflammatory markers in tendon tissue of rats with collagenase-induced Achilles tendinopathy. Cur/PMSs remarkably increased the tensile strength of tendon tissue in a dose-dependent manner. Our findings indicate that Cur/PMSs have great potential for tendon tissue healing and restoration in Achilles tendinopathy.

Original languageEnglish
Pages (from-to)123-130
Number of pages8
JournalJournal of Industrial and Engineering Chemistry
Volume58
DOIs
Publication statusPublished - 2018 Feb 25

Keywords

  • Anti-inflammatory effect
  • Collagenase-induced Achilles tendinopathy
  • Curcumin
  • Porous microspheres
  • Tendon healing

ASJC Scopus subject areas

  • Chemical Engineering(all)

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