In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound

Byung Cheol Lee, Arim Lee, Jee Hyung Jung, Sang Ho Choi, Tae Sung Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Vibrio vulnificus is known to induce severely fulminant and fatal septicemia in susceptible hosts. In the present study, the antimicrobial activity of natural marine product-derived compounds against V. vulnificus, were investigated in vitro and in vivo. Twelve pure compounds were isolated from natural marine products and their inhibitory effects on V. vulnificus-induced cytotoxicity were determined in INT-407 cells. Among the 12 pure compounds tested, treatment with psammaplin A significantly suppressed V. vulnificus-induced cytotoxicity in INT-407 cells. Notably, treatment with psammaplin A (5-50 μg) had improved survival rates compared with that in the untreated mice, when the mice were infected with V. vulnificus intraperitoneally. In addition, the bacterial load of V. vulnificus in several tissues (spleen, liver and small intestine) was significantly lower in psammaplin A-treated mice than in untreated mice. Furthermore, psammaplin A treatment significantly suppressed the growth of V. vulnificus. Taken together, these results indicate that psammaplin A may be a potential agent for the prevention and treatment of V. vulnificus infections.

Original languageEnglish
Pages (from-to)2691-2696
Number of pages6
JournalMolecular Medicine Reports
Volume14
Issue number3
DOIs
Publication statusPublished - 2016 Sep 1

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Keywords

  • Antimicrobial activity
  • Psammaplin A
  • Vibrio vulnificus

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Oncology
  • Genetics
  • Cancer Research

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