In vitro bactericidal and anticancer activity of new metabolite, ARK42, isolated from Aspergillus repens K42

Je Won Park, Beom Seok Song, Dojin Ryu, Chan Lee, Young Bae Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A novel antibacteria metabolite, ARK42, was isolated from a xerophilic fungal strain K42, and identified as Aspergillus repens based on its morphological characteristics. The metabolite exhibited antibacterial activities towards Staphylococcus aureus, Bacillus cereus, and Pseudomonas aeruginosa, with MICs of 25, 12.5, and 3.125 μg/ml, respectively, and killed Pseudomonas aeruginosa with minimal bactericidal concentration (MBC) of 12.5 μg/ml. Furthermore, anticancer activities were demonstrated against human colon cancer DLD-1 and lung cancer LXFL529 cells with an IC50 of 10 and 1 μg/ml, respectively.

Original languageEnglish
Pages (from-to)1017-1021
Number of pages5
JournalJournal of microbiology and biotechnology
Volume12
Issue number6
Publication statusPublished - 2002 Dec

Keywords

  • Anticancer activity
  • Aspergillus repens
  • Bactericidal activity

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology

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