In vitro cytotoxicity of SiO2 or ZnO nanoparticles with different sizes and surface charges on U373MG human glioblastoma cells

Jung Eun Kim, Hyejin Kim, Seong Soo A. An, Eun Ho Maeng, Meyoung-Kon Kim, Yoon Jae Song

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Silicon dioxide (SiO2) and zinc oxide (ZnO) nanoparticles are widely used in various applications, raising issues regarding the possible adverse effects of these metal oxide nanoparticles on human cells. In this study, we determined the cytotoxic effects of differently charged SiO2 and ZnO nanoparticles, with mean sizes of either 100 or 20 nm, on the U373MG human glioblastoma cell line. The overall cytotoxicity of ZnO nanoparticles against U373MG cells was significantly higher than that of SiO2 nanoparticles. Neither the size nor the surface charge of the ZnO nanoparticles affected their cytotoxicity against U373MG cells. The 20 nm SiO2 nanoparticles were more toxic than the 100 nm nanoparticles against U373MG cells, but the surface charge had little or no effect on their cytotoxicity. Both SiO2 and ZnO nanoparticles activated caspase-3 and induced DNA fragmentation in U373MG cells, suggesting the induction of apoptosis. Thus, SiO2 and ZnO nanoparticles appear to exert cytotoxic effects against U373MG cells, possibly via apoptosis.

Original languageEnglish
Pages (from-to)235-241
Number of pages7
JournalInternational Journal of Nanomedicine
Volume9
DOIs
Publication statusPublished - 2014 Dec 15

Fingerprint

Zinc Oxide
Glioblastoma
Cytotoxicity
Surface charge
Zinc oxide
Nanoparticles
Cell death
Metal Nanoparticles
Apoptosis
Cells
In Vitro Techniques
Poisons
DNA Fragmentation
Caspase 3
Silicon Dioxide
Oxides
DNA
Metals
Silica
Cell Line

Keywords

  • Apoptosis

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Drug Discovery
  • Organic Chemistry

Cite this

In vitro cytotoxicity of SiO2 or ZnO nanoparticles with different sizes and surface charges on U373MG human glioblastoma cells. / Kim, Jung Eun; Kim, Hyejin; An, Seong Soo A.; Maeng, Eun Ho; Kim, Meyoung-Kon; Song, Yoon Jae.

In: International Journal of Nanomedicine, Vol. 9, 15.12.2014, p. 235-241.

Research output: Contribution to journalArticle

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