In Vitro Effect of Clinical Propofol Concentrations on Platelet Aggregation

Hye Gyo Chung, Soohyun A. Myung, Ho Sung Son, Yun-Hee Kim, Jin Namgung, Mi La Cho, Hyuk Choi, Choon Hak Lim

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The inhibitory effect of propofol on platelet aggregation remains unclear, and studies on the subject disagree. Furthermore, although propofol infusions are widely used for general anesthesia and as sedatives for patients in intensive care units, little information is available on its concentration- and time-related effects on platelet aggregation. Here, the authors investigated the in vitro effect of propofol, at concentrations required for sedation and general anesthesia, on platelet aggregation after 1, 2, or 3h. Blood from healthy volunteers (n=9) was incubated at propofol plasma concentrations of 0, 2, 4, and 10μg/mL in a water bath at 37°C. Platelet aggregation was measured using a platelet function analyzer (PFA-100) after 1, 2, or 3h of incubation. Times to occlude collagen/epinephrine (CEPI) or collagen/adenosine 5'-diphosphate (CADP)-coated membranes (closure times, CTs) were measured. The CEPI and CADP CTs of non-incubated blood were 125.6±19.5s and 93.0±12.2s, respectively, and no significant difference in CEPI CTs was observed at propofol plasma concentrations of 0, 2, 4, and 10μg/mL after incubation for 1, 2, or 3h. CADP CTs were comparable at propofol concentrations of 0, 2, 4, and 10μg/mL at each incubation time. These findings suggest that propofol at concentrations required for sedation and general anesthesia has no inhibitory effect on platelet aggregation after 3h of incubation.

Original languageEnglish
JournalArtificial Organs
Volume37
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

    Fingerprint

Keywords

  • In vitro
  • Platelet aggregation
  • Propofol anesthesia

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Bioengineering
  • Medicine (miscellaneous)

Cite this