In vitro mammary duct reconstruction based localized collagen extracellular matrix in microfluidic platform

Youngkyu Cho, Su Hyun Lee, Yoojin Shin, Jaehoon Kim, Seok Chung, Woo Kyung Moon

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Reconstruction of mammary duct in vitro is highly required to study breast cancer pathology in progressing invasive ductal carcinoma in situ (DCIS) [1]. 30% of DCIS cases were known to have invasive character, which is strongly associated with cancer malignancy. Understanding the invasive transition needs an in vitro model with modulating capability on microenvironment, consisting of mammary duct, stromal cells and extracellular matrix (ECM). Here, we mimicked the mammary duct in microfluidic platform in 3D on type I collagen ECM. Morphologies and functions of the mammary duct were confirmed by 3D lumen structure, junction proteins and permeability.

Original languageEnglish
Title of host publication20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PublisherChemical and Biological Microsystems Society
Pages525-526
Number of pages2
ISBN (Electronic)9780979806490
Publication statusPublished - 2016
Event20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 - Dublin, Ireland
Duration: 2016 Oct 92016 Oct 13

Other

Other20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
CountryIreland
CityDublin
Period16/10/916/10/13

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Keywords

  • Mammary duct
  • Microfluidics

ASJC Scopus subject areas

  • Control and Systems Engineering

Cite this

Cho, Y., Lee, S. H., Shin, Y., Kim, J., Chung, S., & Moon, W. K. (2016). In vitro mammary duct reconstruction based localized collagen extracellular matrix in microfluidic platform. In 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016 (pp. 525-526). Chemical and Biological Microsystems Society.