In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

Youn Chul Kim, Hyuncheol Oh, Beom Seok Kim, Tai Hyun Kang, Eun Kyoung Ko, Yu Mi Han, Bo Yeon Kim, Jong Seog Ahn

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for B diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 ± 0.5 μM and 20.8 ± 1.9 μM, respectively.

Original languageEnglish
Pages (from-to)87-89
Number of pages3
JournalPlanta Medica
Volume71
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1
Externally publishedYes

Fingerprint

Psoralea
Cullen corylifolium
Non-Receptor Type 1 Protein Tyrosine Phosphatase
protein-tyrosine-phosphatase
Phenols
phenols
Seed
Seeds
seeds
Bioassay
seed extracts
Fractionation
Medical problems
Biological Assay
Inhibitory Concentration 50
inhibitory concentration 50
diabetes
fractionation
insulin
bioassays

ASJC Scopus subject areas

  • Plant Science
  • Drug Discovery
  • Organic Chemistry
  • Pharmacology

Cite this

In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia. / Kim, Youn Chul; Oh, Hyuncheol; Kim, Beom Seok; Kang, Tai Hyun; Ko, Eun Kyoung; Han, Yu Mi; Kim, Bo Yeon; Ahn, Jong Seog.

In: Planta Medica, Vol. 71, No. 1, 01.01.2005, p. 87-89.

Research output: Contribution to journalArticle

Kim, Youn Chul ; Oh, Hyuncheol ; Kim, Beom Seok ; Kang, Tai Hyun ; Ko, Eun Kyoung ; Han, Yu Mi ; Kim, Bo Yeon ; Ahn, Jong Seog. / In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia. In: Planta Medica. 2005 ; Vol. 71, No. 1. pp. 87-89.
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