In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia

Youn Chul Kim, Hyuncheol Oh, Beom Seok Kim, Tai Hyun Kang, Eun Kyoung Ko, Yu Mi Han, Bo Yeon Kim, Jong Seog Ahn

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Protein tyrosine phosphatase 1B plays a major role in the negative regulation of insulin signaling, and this establishes protein tyrosine phosphatase 1B as an attractive therapeutic target for B diabetes. Bioassay-guided fractionation of the EtOAc-soluble extract of the seeds of Psoralea corylifolia afforded two protein tyrosine phosphatase 1B inhibitory compounds, psoralidin (1) and bakuchiol (2), along with inactive corylin. Compounds 1 and 2 inhibited PTP1B activity in a dose-dependent manner, displaying IC50 values of 9.4 ± 0.5 μM and 20.8 ± 1.9 μM, respectively.

Original languageEnglish
Pages (from-to)87-89
Number of pages3
JournalPlanta Medica
Volume71
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1

    Fingerprint

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Cite this

Kim, Y. C., Oh, H., Kim, B. S., Kang, T. H., Ko, E. K., Han, Y. M., Kim, B. Y., & Ahn, J. S. (2005). In vitro protein tyrosine phosphatase 1B inhibitory phenols from the seeds of Psoralea corylifolia. Planta Medica, 71(1), 87-89. https://doi.org/10.1055/s-2005-837759