In vivo assessment of the effect of taxifolin glycoside on atopic dermatitis-like skin lesions using biomedical tools in NC/Nga mice

J. Y. Kim, O. S. Lee, S. Ha, J. H. Kim, G. Park, J. K. Kim, Chil Hwan Oh

    Research output: Contribution to journalArticlepeer-review

    9 Citations (Scopus)

    Abstract

    Background Noninvasive methods of assessment are widely used in clinical trials. However, such methods have not been established in atopic dermatitis (AD), which is a chronic inflammatory skin disease. Aim To demonstrate, using biomedical tools, the benefits of a new substance, taxifolin glycoside (TAX), in an AD model, the NC/Nga mouse. Methods We evaluated the efficacy of topical TAX for AD by measuring clinical skin severity score, cytokine expression and serum IgE level, and by using biomedical measures (vapometry and corneometry). Topical TAX was applied to AD-induced NC/Nga mice for 3 weeks. The anti-inflammatory effects of this compound were demonstrated noninvasively using biomedical tools and immunological assays. Results Our method of AD assessment using biomedical tools is more objective and accurate than visual inspection. The results obtained using the biomedical tools were identical to those obtained using immunological assays. Conclusions In vivo biomedical tools are useful for diagnosing and monitoring treatment effects in AD.

    Original languageEnglish
    Pages (from-to)547-555
    Number of pages9
    JournalClinical and Experimental Dermatology
    Volume40
    Issue number5
    DOIs
    Publication statusPublished - 2015 Jul 1

    ASJC Scopus subject areas

    • Dermatology

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