In vivo biocompatibilty and degradation behavior of elastic poly(L-lactide-co-ε-caprolactone) scaffolds

Sung In Jeong, Byung Soo Kim, Sun Woong Kang, Jae Hyun Kwon, Young Moo Lee, Soo Hyun Kim, Young Ha Kim

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Tubular scaffolds were fabricated from very elastic poly(L-lactide-co- ε-caprolactone) (PLCL, 50:50). The scaffolds were seeded with smooth muscle cells (SMCs) and implanted in nude mice to investigate the tissue compatibility and in vivo degradation behavior. Histological examination of all the implants with haematoxylin and eosin staining, masson trichrome staining, SM α-actin antibody, and CM-DiI labeling confirmed that the regular morphology and biofunction of the SMCs seeded and the expression of the vascular smooth muscle matrices in PLCL scaffolds. The implanted PLCL scaffolds displayed a slow degradation on time, where caprolactone units were faster degraded than lactide did. This could be explained by the fact that amorphous regions composed of mainly CL moieties degraded earlier than hard domains where most of the LA units were located. From these results, the scaffolds applied in this study were found to exhibit excellent tissue compatibility to SMCs and might be very useful for vascular tissue engineering.

Original languageEnglish
Pages (from-to)5939-5946
Number of pages8
JournalBiomaterials
Volume25
Issue number28
DOIs
Publication statusPublished - 2004 Dec 1
Externally publishedYes

Keywords

  • Biodegradation
  • Compatibility to smooth muscle cells
  • Elastic PLCL scaffolds

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

Fingerprint Dive into the research topics of 'In vivo biocompatibilty and degradation behavior of elastic poly(L-lactide-co-ε-caprolactone) scaffolds'. Together they form a unique fingerprint.

  • Cite this

    Jeong, S. I., Kim, B. S., Kang, S. W., Kwon, J. H., Lee, Y. M., Kim, S. H., & Kim, Y. H. (2004). In vivo biocompatibilty and degradation behavior of elastic poly(L-lactide-co-ε-caprolactone) scaffolds. Biomaterials, 25(28), 5939-5946. https://doi.org/10.1016/j.biomaterials.2004.01.057