In vivo evaluation of the pulsatile ECLS sysem

Hwan Sung Lee, Yang Rae Rho, Hyuk Soo Lee, Chang Mo Hwang, Seong Wook Choi, Jung Chan Lee, Hyuk Choi, Sang Su Ahn, Kyung Sun, Ho Sung Son, Kwang Je Baek, Yong Soon Won, Byoung Goo Min

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Extracorporeal life support (ECLS) systems have been increasingly applied to groups of patients with cardiorespiratory failure, including pediatric and adult patients with respiratory failure. Current pulsatile ECLS systems use a single pulsatile blood pump that generates a high inlet pressure in the membrane oxygenator. To minimize this high inlet pressure, we have developed a new and improved ECLS system, twin pulse life support (T-PLS). To analyze the advantages of T-PLS, we have compared T-PLS with a single pulsatile ECLS system. An acute heart failure model was constructed by using a pulmonary artery banding technique. Fourteen pigs (22-31 kg) were used, with cardiac outputs of 2.01/min and a V/Q ratio set at 1. Cannulae of 28Fr and 18Fr were used in the right atrium and aorta, respectively. A polypropylene hollow-fiber membrane oxygenator and four polymer valves 30 mm in diameter were used in the T-PLS system. In the single pulsatile ECLS system, Medtronic Hall monostrut valves were used. To evaluate blood cell trauma in both pulsatile ECLS systems, plasma free hemoglobin (fHb) was measured while the systems were in use. The results show that fHb levels in T-PLS are lower than fHb levels in the single pulsatile ECLS system. There is a possibility that T-PLS could be used as an ECLS system for emergency situations.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalJournal of Artificial Organs
Volume6
Issue number1
DOIs
Publication statusPublished - 2003 May 20

Fingerprint

Life Support Systems
Extracorporeal Membrane Oxygenation
Hemoglobin
Oxygenators
Hemoglobins
Pulse
Blood
Membranes
Pediatrics
Polypropylenes
Membrane Oxygenators
Polymers
Cells
Pumps
Plasmas
Fibers
Pressure
Heart Atria
Respiratory Insufficiency
Cardiac Output

Keywords

  • ECLS
  • Plasma free hemoglobin
  • Pulsatile ECLS system

ASJC Scopus subject areas

  • Biophysics

Cite this

Lee, H. S., Rho, Y. R., Lee, H. S., Hwang, C. M., Choi, S. W., Lee, J. C., ... Min, B. G. (2003). In vivo evaluation of the pulsatile ECLS sysem. Journal of Artificial Organs, 6(1), 25-29. https://doi.org/10.1007/s100470300004

In vivo evaluation of the pulsatile ECLS sysem. / Lee, Hwan Sung; Rho, Yang Rae; Lee, Hyuk Soo; Hwang, Chang Mo; Choi, Seong Wook; Lee, Jung Chan; Choi, Hyuk; Ahn, Sang Su; Sun, Kyung; Son, Ho Sung; Baek, Kwang Je; Won, Yong Soon; Min, Byoung Goo.

In: Journal of Artificial Organs, Vol. 6, No. 1, 20.05.2003, p. 25-29.

Research output: Contribution to journalArticle

Lee, HS, Rho, YR, Lee, HS, Hwang, CM, Choi, SW, Lee, JC, Choi, H, Ahn, SS, Sun, K, Son, HS, Baek, KJ, Won, YS & Min, BG 2003, 'In vivo evaluation of the pulsatile ECLS sysem', Journal of Artificial Organs, vol. 6, no. 1, pp. 25-29. https://doi.org/10.1007/s100470300004
Lee HS, Rho YR, Lee HS, Hwang CM, Choi SW, Lee JC et al. In vivo evaluation of the pulsatile ECLS sysem. Journal of Artificial Organs. 2003 May 20;6(1):25-29. https://doi.org/10.1007/s100470300004
Lee, Hwan Sung ; Rho, Yang Rae ; Lee, Hyuk Soo ; Hwang, Chang Mo ; Choi, Seong Wook ; Lee, Jung Chan ; Choi, Hyuk ; Ahn, Sang Su ; Sun, Kyung ; Son, Ho Sung ; Baek, Kwang Je ; Won, Yong Soon ; Min, Byoung Goo. / In vivo evaluation of the pulsatile ECLS sysem. In: Journal of Artificial Organs. 2003 ; Vol. 6, No. 1. pp. 25-29.
@article{76319ae568bc4eb985ee0d9b080c1154,
title = "In vivo evaluation of the pulsatile ECLS sysem",
abstract = "Extracorporeal life support (ECLS) systems have been increasingly applied to groups of patients with cardiorespiratory failure, including pediatric and adult patients with respiratory failure. Current pulsatile ECLS systems use a single pulsatile blood pump that generates a high inlet pressure in the membrane oxygenator. To minimize this high inlet pressure, we have developed a new and improved ECLS system, twin pulse life support (T-PLS). To analyze the advantages of T-PLS, we have compared T-PLS with a single pulsatile ECLS system. An acute heart failure model was constructed by using a pulmonary artery banding technique. Fourteen pigs (22-31 kg) were used, with cardiac outputs of 2.01/min and a V/Q ratio set at 1. Cannulae of 28Fr and 18Fr were used in the right atrium and aorta, respectively. A polypropylene hollow-fiber membrane oxygenator and four polymer valves 30 mm in diameter were used in the T-PLS system. In the single pulsatile ECLS system, Medtronic Hall monostrut valves were used. To evaluate blood cell trauma in both pulsatile ECLS systems, plasma free hemoglobin (fHb) was measured while the systems were in use. The results show that fHb levels in T-PLS are lower than fHb levels in the single pulsatile ECLS system. There is a possibility that T-PLS could be used as an ECLS system for emergency situations.",
keywords = "ECLS, Plasma free hemoglobin, Pulsatile ECLS system",
author = "Lee, {Hwan Sung} and Rho, {Yang Rae} and Lee, {Hyuk Soo} and Hwang, {Chang Mo} and Choi, {Seong Wook} and Lee, {Jung Chan} and Hyuk Choi and Ahn, {Sang Su} and Kyung Sun and Son, {Ho Sung} and Baek, {Kwang Je} and Won, {Yong Soon} and Min, {Byoung Goo}",
year = "2003",
month = "5",
day = "20",
doi = "10.1007/s100470300004",
language = "English",
volume = "6",
pages = "25--29",
journal = "Journal of Artificial Organs",
issn = "1434-7229",
publisher = "Springer Japan",
number = "1",

}

TY - JOUR

T1 - In vivo evaluation of the pulsatile ECLS sysem

AU - Lee, Hwan Sung

AU - Rho, Yang Rae

AU - Lee, Hyuk Soo

AU - Hwang, Chang Mo

AU - Choi, Seong Wook

AU - Lee, Jung Chan

AU - Choi, Hyuk

AU - Ahn, Sang Su

AU - Sun, Kyung

AU - Son, Ho Sung

AU - Baek, Kwang Je

AU - Won, Yong Soon

AU - Min, Byoung Goo

PY - 2003/5/20

Y1 - 2003/5/20

N2 - Extracorporeal life support (ECLS) systems have been increasingly applied to groups of patients with cardiorespiratory failure, including pediatric and adult patients with respiratory failure. Current pulsatile ECLS systems use a single pulsatile blood pump that generates a high inlet pressure in the membrane oxygenator. To minimize this high inlet pressure, we have developed a new and improved ECLS system, twin pulse life support (T-PLS). To analyze the advantages of T-PLS, we have compared T-PLS with a single pulsatile ECLS system. An acute heart failure model was constructed by using a pulmonary artery banding technique. Fourteen pigs (22-31 kg) were used, with cardiac outputs of 2.01/min and a V/Q ratio set at 1. Cannulae of 28Fr and 18Fr were used in the right atrium and aorta, respectively. A polypropylene hollow-fiber membrane oxygenator and four polymer valves 30 mm in diameter were used in the T-PLS system. In the single pulsatile ECLS system, Medtronic Hall monostrut valves were used. To evaluate blood cell trauma in both pulsatile ECLS systems, plasma free hemoglobin (fHb) was measured while the systems were in use. The results show that fHb levels in T-PLS are lower than fHb levels in the single pulsatile ECLS system. There is a possibility that T-PLS could be used as an ECLS system for emergency situations.

AB - Extracorporeal life support (ECLS) systems have been increasingly applied to groups of patients with cardiorespiratory failure, including pediatric and adult patients with respiratory failure. Current pulsatile ECLS systems use a single pulsatile blood pump that generates a high inlet pressure in the membrane oxygenator. To minimize this high inlet pressure, we have developed a new and improved ECLS system, twin pulse life support (T-PLS). To analyze the advantages of T-PLS, we have compared T-PLS with a single pulsatile ECLS system. An acute heart failure model was constructed by using a pulmonary artery banding technique. Fourteen pigs (22-31 kg) were used, with cardiac outputs of 2.01/min and a V/Q ratio set at 1. Cannulae of 28Fr and 18Fr were used in the right atrium and aorta, respectively. A polypropylene hollow-fiber membrane oxygenator and four polymer valves 30 mm in diameter were used in the T-PLS system. In the single pulsatile ECLS system, Medtronic Hall monostrut valves were used. To evaluate blood cell trauma in both pulsatile ECLS systems, plasma free hemoglobin (fHb) was measured while the systems were in use. The results show that fHb levels in T-PLS are lower than fHb levels in the single pulsatile ECLS system. There is a possibility that T-PLS could be used as an ECLS system for emergency situations.

KW - ECLS

KW - Plasma free hemoglobin

KW - Pulsatile ECLS system

UR - http://www.scopus.com/inward/record.url?scp=12444335265&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=12444335265&partnerID=8YFLogxK

U2 - 10.1007/s100470300004

DO - 10.1007/s100470300004

M3 - Article

C2 - 14598121

AN - SCOPUS:12444335265

VL - 6

SP - 25

EP - 29

JO - Journal of Artificial Organs

JF - Journal of Artificial Organs

SN - 1434-7229

IS - 1

ER -